Molecular Glues Modulators

Featured Inhibitors
Inhibitors (3)
Modulators (3)
Chemicals (4)

Cat.No.	Product Name	Information	Product Use Citations
S8975	Mezigdomide (CC-92480)	Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.	Nat Commun, 2024, 15(1):8885 Mol Cancer Ther, 2023, 22(5):659-666 Nature Communications, 15 October 2024, 8885
E1847	GBD-9	GBD-9 is a double-mechanism efficient degrader of BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). This compound acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. It exhibits anti-proliferative effects, inhibiting cancer cell survival.
E1965	NST-628	NST-628 is a potent and well-tolerated single-agent inhibitor of both RAF and MEK. It acts as a pan-RAF–MEK molecular glue that blocks the phosphorylation and activation of MEK by RAF.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8975

Mezigdomide (CC-92480)

Mezigdomide (CC-92480) is a novel protein degrader and a cereblon E3 ligase modulator (CELMoD) that has anti-myeloma activity.

Nat Commun, 2024, 15(1):8885

Mol Cancer Ther, 2023, 22(5):659-666

Nature Communications, 15 October 2024, 8885

E1847

GBD-9

GBD-9 is a double-mechanism efficient degrader of BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). This compound acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. It exhibits anti-proliferative effects, inhibiting cancer cell survival.

E1965

NST-628

NST-628 is a potent and well-tolerated single-agent inhibitor of both RAF and MEK. It acts as a pan-RAF–MEK molecular glue that blocks the phosphorylation and activation of MEK by RAF.