Home Metabolism Lipid

Lipid Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. This compound binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. It suppresses growth and enhances apoptosis in cancer cells.
J Transl Med, 2025, 23(1):1055
iScience, 2025, 28(8):113097
Oncol Lett, 2025, 29(4):175
S4223 Mevastatin Mevastatin (ML-236B,Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
J Immunother Cancer, 2024, 12(11)e009805
Nat Cardiovasc Res, 2023, 2(6):550-571
Immunity, 2021, 54(10):2273-2287.e6
Verified customer review of Mevastatin
S4754 Betulin Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. This compound (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.
Acta Biochim Biophys Sin -Shanghai), 2023, 55(9):1479-1486
Acta Biochim Biophys Sin (Shanghai), 2023, 55(9):1479-1486
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S6418 PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM).
Cell Rep, 2023, 42(6):112586
Nat Commun, 2019, 11;10(1):4621
E0008 Atractylodin Atractylodin (Atractydin) is one of the major constituents of the rhizome of Atractylodes lancea and inhibits N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity with an IC50 of 2.81 µM. This compound also inhibits interleukin-6 (IL-6) by blocking NPM-ALK activation and MAPKs.
E5796 CAY10499 CAY10499 (MAGL-IN-5) is a non-selective lipase inhibitor with IC₅₀ values of 144 nM for human recombinant monoacylglycerol lipase (MAGL), 90 nM for hormone-sensitive lipase (HSL), and 14 nM for fatty acid amide hydrolase (FAAH). It also inhibits cell growth in MCF-7, MB-231, COV318, OVCAR-3 cancer cell lines.
S4930 Cetilistat Cetilistat (ATL962) is a novel highly lipophilic benzoxazinone that inhibits gastrointestinal and pancreatic lipases. It shows a good safety and tolerability profile in vivo