Integrin Antagonists

Cat.No.	Product Name	Information	Product Use Citations
S8454	ATN-161	ATN-161 is a novel small peptide antagonist of integrin α5β1. It binds to several integrins, including α5β1 and αvβ3, that play a role in angiogenesis and tumor progression.	Nat Commun, 2025, 16(1):6531 Nat Commun, 2025, 16(1):9183 Regen Biomater, 2025, 12:rbaf099
S3714	Lifitegrast	Lifitegrast (SAR1118,SHP-606) is a novel small molecule integrin antagonist that inhibits a specific T cell-mediated inflammatory pathway involved in the pathogenesis of DED.	Med Oncol, 2024, 41(8):188 World J Gastroenterol, 2023, 29(20):3103-3118 Med Chem Res, 2022, 31(4):555-579
S8594	Tirofiban Hydrochloride	Tirofiban Hydrochloride (MK-383) is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.	J Immunother Cancer, 2024, 12(11)e009805 Transl Oncol, 2024, 39:101813 Front Cell Infect Microbiol, 2021, 11:783085
S3085	Tirofiban	Tirofiban (MK-383) is a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.	Food Funct, 2020, 11(1):139-152
E4615	GLPG0187	GLPG0187 is a broad-spectrum antagonist of integrin receptor. It inhibits αvβ1-integrin with an IC50 value of 1.3 nM. This compound also inhibits migrasome biogenesis without cytotoxicity. It exhibits potent antitumor activity.	Sci Rep, 2025, 15(1):9147
E1558	GSK-3008348 HCl	GSK-3008348 HCl is a small molecule antagonist of integrin αvβ6 with an affinity (pIC50) value of 8.1 for αvβ6 in cell Adhesion assays.
S0314	TR-14035	TR-14035 (SB 683698, MDK-1191) is a a dual alpha4beta (α4β) integrin antagonist with IC50 of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively.
E6559^New	GS-1427	GS-1427 (Emvistegrast) is an oral, small-molecule quinolone derivative that functions as a potent and selective antagonist of α4β7 integrin, with the potential treatment of inflammatory bowel disease.