IFN Agonists

Featured Inhibitors
Inhibitors (12)
Chemical (1)
Agonists (2)
Activators (6)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S0289	KIN1148	KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. This compound is an influenza vaccine adjuvant that enhances flu vaccine efficacy.	Journal of Allergy and Clinical Immunology, 2023, 509-525.e8 Journal of Allergy and Clinical Immunology, 2023, 509-525.e8 J Allergy Clin Immunol, 2022, S0091-6749(22)01423-3
E0448	RO8191	RO8191 (CDM-3008, RO4948191), an imidazonaphthyridine compound, is an orally active and potent agonist of interferon (IFN) receptor. This compound binds directly to the IFNα/β receptor 2 (IFNAR2), activating IFN-stimulated genes (ISGs) expression and the phosphorylation of JAK/STAT signaling.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S0289

KIN1148

KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. This compound is an influenza vaccine adjuvant that enhances flu vaccine efficacy.

Journal of Allergy and Clinical Immunology, 2023, 509-525.e8

J Allergy Clin Immunol, 2022, S0091-6749(22)01423-3

E0448

RO8191

RO8191 (CDM-3008, RO4948191), an imidazonaphthyridine compound, is an orally active and potent agonist of interferon (IFN) receptor. This compound binds directly to the IFNα/β receptor 2 (IFNAR2), activating IFN-stimulated genes (ISGs) expression and the phosphorylation of JAK/STAT signaling.