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Australia
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Austria
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Belgium
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Brazil
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Canada
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China
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Czech Republic
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Denmark
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Finland
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France
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Germany
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Greece
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Hong Kong
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Hungary
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Iceland
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India
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Ireland
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Israel
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Italy
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Japan
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Korea
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Luxembourg
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Malaysia
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Netherlands
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New Zealand
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Norway
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Poland
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Qatar
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Romania
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Saudi Arabia
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Singapore
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Spain
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Sweden
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Switzerland
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Taiwan
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Turkey
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United Kingdom
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United States
Histone Methyltransferase Antagonists
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S2184 | WDR5-0103 | WDR5-0103 (WD-Repeat Protein 5-0103) is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. |
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| S8359 | UNC3866 | UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. This compound binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains. |
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| S7833 | OICR-9429 | OICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro. It binds to WDR5 with high affinity (KD = 93 ± 28 nM. |
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