Histone Methyltransferase Chemical

Featured Inhibitors
Inhibitors (62)
Chemical (1)
Antagonists (3)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8496	EED226	EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.	Protein Cell, 2025, 16(6):439-457 Cell Rep, 2025, 44(3):115362 iScience, 2025, 28(7):112905

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8496

EED226

EED226 is a potent, selective, and orally bioavailable a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor with an IC50 of 23.4 nM when the H3K27me0 peptide was used as substrate and an IC50 of 53.5 nM when the mononucleosome was used as the substrate. It directly binds to the H3K27me3 binding pocket of EED.

Protein Cell, 2025, 16(6):439-457

Cell Rep, 2025, 44(3):115362

iScience, 2025, 28(7):112905