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Inhibitors (55)
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Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S1526	Quizartinib (AC220)	Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.	Signal Transduct Target Ther, 2025, 10(1):222 Leukemia, 2025, 39(9):2152-2162 EMBO Mol Med, 2025, 10.1038/s44321-025-00296-2

Cat.No.

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Information

Product Use Citations

Product Validations

S1526

Quizartinib (AC220)

Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3.

Signal Transduct Target Ther, 2025, 10(1):222

Leukemia, 2025, 39(9):2152-2162

EMBO Mol Med, 2025, 10.1038/s44321-025-00296-2

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