ERK Modulators

Cat.No.	Product Name	Information	Product Use Citations
S0881	Mitochonic acid 5 (MA-5)	Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy, regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway, and modulates mitochondrial ATP synthesis.	Front Cell Dev Biol, 2025, 13:1583951 Animals (Basel), 2024, 14(3):368. Animals (Basel), 2024, 14(3)368
S8961	Alobresib (GS-5829)	Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. This compound inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. It also inhibits NF-κB signaling.
S3284	Tracheloside	Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. This compound significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. It promotes keratinocyte proliferation through ERK1/2 stimulation.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S0881

Mitochonic acid 5 (MA-5)

Mitochonic acid 5 (MA-5) reduces mitochondrial apoptosis via upregulation of mitophagy, regulates mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway, and modulates mitochondrial ATP synthesis.

Front Cell Dev Biol, 2025, 13:1583951

Animals (Basel), 2024, 14(3):368.

Animals (Basel), 2024, 14(3)368

S8961

Alobresib (GS-5829)

Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. This compound inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. It also inhibits NF-κB signaling.

S3284

Tracheloside

Tracheloside is a lignan glycoside isolated from seeds of Carthamus tinctorius with anti-estrogenic effects. This compound significantly decreases the activity of alkaline phosphatase (AP) (an estrogen-inducible marker enzyme) with IC50 of 0.31 μg/ml. It promotes keratinocyte proliferation through ERK1/2 stimulation.