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Myc Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7153 10058-F4 10058-F4 is a c-Myc inhibitor that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 promotes a caspase-3-dependent apoptosis and modulates autophagy.
Nat Commun, 2025, 16(1):138
Int J Biol Sci, 2025, 21(6):2762-2779
Cell Death Dis, 2025, 16(1):601
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S8906 MYCi975 MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. This compound exhibits potent anti-tumor activities.
Nature, 2025, 646(8085):707-715
Cell Rep, 2025, 44(6):115722
Mol Cancer Ther, 2025, 10.1158/1535-7163.MCT-25-0136
S8426 10074-G5 10074-G5 is a c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 µM).
J Exp Clin Cancer Res, 2025, 44(1):70
Acta Neuropathol Commun, 2025, 13(1):139
Cell Death Dis, 2024, 15(11):861
S8905 MYCi361 MYCi361 is a MYC inhibitor that engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. This compound binds to MYC with Kd of 3.2 μM. It suppresses in vivo tumor growth, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
Cells, 2025, 14(10)709
RSC Chem Biol, 2025, 10.1039/d5cb00093a
Haematologica, 2024, 109(12):3989-4006
S9807 EN4 EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. This compound inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
Cell Rep, 2025, 44(3):115327
Nat Commun, 2024, 15(1):3905
Cell Rep, 2023, 42(11):113198
S6963 APTO-253

APTO-253 (LOR-253, LT-253) inhibits c-Myc expression and selectively induces CDKN1A (p21), promotes G0-G1 cell-cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. This compound is also an inducer of KLF4 (Krüppel-like factor 4).
Cell Commun Signal, 2023, 21(1):94
S0249 Mycro 3 Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. This compound also shows weak inhibitory activity against AP-1.
J Biol Chem, 2025, S0021-9258(25)00377-1
E4750New Cpd. 37 MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.
S0103 ML327 ML327 is an isoxazole compound that blocks MYC expression and tumor formation in neuroblastoma. This compound also restores E-cadherin expression with In-Cell Western EC50 of 1.0 μM. It induces apoptosis.
S0987 MYCMI-6 MYCMI-6 (NSC354961) is a potent and selective endogenous inhibitor of MYC:MAX protein interactions. This compound blocks MYC-driven transcription and binds to the MYC bHLHZip domain with Kd of 1.6 μM. It inhibits tumor cell growth in a MYC-dependent manner with IC50 of <0.5 μM. This chemical induces apoptosis.
S9871 BTYNB BTYNB (BTYNB IMP1 Inhibitor, MDK6620) is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA. This compound downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association.
S1109 BI 2536 BI-2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. BI-2536 inhibits Bromodomain 4 (BRD4) with Kd of 37 nM and potently suppresses c-Myc expression. BI-2536 induces apoptosis and attenuates autophagy. Phase 2.
Gut, 2025, gutjnl-2024-334274
Nat Commun, 2025, 16(1):1599
Genome Biol, 2025, 26(1):204
Verified customer review of BI 2536
S9667 Inobrodib (CCS-1477) Inobrodib (CCS1477; CBP-IN-1; CBP/p300-IN-4）is a potent and selective inhibitor of p300/CBP bromodomain. CCS1477 works by inhibiting the expression and function of the androgen receptor (AR), as well as inhibiting c-Myc.
Nat Genet, 2025, 57(10):2468-2481
Nat Commun, 2025, 16(1):4133
PLoS Pathog, 2025, 21(9):e1013073
E1882 THZ1 THZ1 is a potent and covalent inhibitor of CDK7 with an IC50 of 3.2 nM. It also inhibits the CDK12 and CDK13 and downregulates MYC expression. It exhibits strong anti proliferative effect across a broad range of cancer cell lines including human T-cell acute lymphoblastic leukaemia (T-ALL) cancer.