Home GPCR & G Protein Hedgehog/Smoothened

Hedgehog/Smoothened Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S7779 SAG (Smoothened Agonist) Hydrochloride SAG (Smoothened Agonist) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
J Orthop Res, 2026, 44(4):e70183
Nat Commun, 2025, 16(1):6545
Nat Commun, 2025, 16(1):1267
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S3042 Purmorphamine Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.
Pharmacol Res, 2026, 224:108103
Nat Commun, 2025, 16(1):8693
Commun Biol, 2025, 8(1):1177
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S6384 SAG (Smoothened Agonist) SAG (Smoothened Agonist) is a potent agonist of Smoothened (Smo). Smoothened Agonist induces firefly luciferase expression in Shh-LIGHT2 cells with an EC50 of 3 nM.
Stem Cell Reports, 2026, 21(3):102781
CNS Neurosci Ther, 2026, 32(1):e70763
Cell Rep, 2025, 44(5):115597