Home GPCR & G Protein S1P Receptor

S1P Receptor Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S5002 FTY720 (Fingolimod) Hydrochloride Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
Cancer Cell, 2025, S1535-6108(25)00319-8
Nat Commun, 2025, 16(1):9175
Nat Commun, 2025, 16(1):1826
Verified customer review of FTY720 (Fingolimod) Hydrochloride
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
Cell Death Dis, 2025, 16(1):282
Front Pharmacol, 2024, 15:1494210
Cell Res, 2022, 10.1038/s41422-022-00614-0
E1158 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM.
Cell Death Dis, 2025, 16(1):282
J Transl Med, 2025, 23(1):573
E2363 Etrasimod(APD334) Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.
S7181 W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.