Home GPCR & G Protein S1P Receptor

S1P Receptor Antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S5002 FTY720 (Fingolimod) Hydrochloride Fingolimod (FTY720, Fingolimod Hydrochloride) HCl is a S1P antagonist with IC50 of 0.033 nM in K562, and NK cells. Please use saline solution rather than PBS for dilutions. PBS may cause precipitation.
Cancer Cell, 2025, S1535-6108(25)00319-8
Nat Commun, 2025, 16(1):9175
Nat Commun, 2025, 16(1):1826
Verified customer review of FTY720 (Fingolimod) Hydrochloride
S7182 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
eLife, September 17, 2020, e60541
Cancer Management and Research, August 26, 2020, 7857-7865
Cell Death Dis, 2025, 16(1):282
E1158 CAY10444 CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist, which can inhibit S1P response of S1P3 cell line with 78% inhibition rate and IC50 of 4.6 μM.
Cell Death Dis, 2025, 16(1):282
J Transl Med, 2025, 23(1):573
S7181 W146 W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. It may exhibit potential clinical applications in multiple sclerosis, coronary artery disease, diabetes, and cancer treatment.
The American Journal of Pathology, 2018 Sep, 2042-2058
E2363 Etrasimod(APD334) Etrasimod(APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an EC50 value of 1.88 nM in CHO cells.