S1P Receptor Activators

Cat.No.	Product Name	Information	Product Use Citations
E2411	Taurodeoxycholic acid sodium hydrate	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
S7791	PMA chemical (Phorbol 12-myristate 13-acetate)	PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.	Protein Cell, 2025, pwaf020 Nat Commun, 2025, 16(1):8054 Cancer Commun (Lond), 2025, 10.1002/cac2.70036
E1218	K6PC-5	K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.	Cell Prolif, 2024, e13604. Int J Biol Sci, 2022, 18(7):2994-3005

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E2411

Taurodeoxycholic acid sodium hydrate

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

S7791

PMA chemical (Phorbol 12-myristate 13-acetate)

PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.

Protein Cell, 2025, pwaf020

Nat Commun, 2025, 16(1):8054

Cancer Commun (Lond), 2025, 10.1002/cac2.70036

E1218

K6PC-5

K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.

Cell Prolif, 2024, e13604.

Int J Biol Sci, 2022, 18(7):2994-3005