S1P Receptor Activators

Cat.No.	Product Name	Information	Product Use Citations
E2411	Taurodeoxycholic acid sodium hydrate	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.
S7791	PMA chemical (Phorbol 12-myristate 13-acetate)	PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.	bioRxiv, March 14, 2026, Preprint Scientific Reports, January 31, 2022, 1626 Clinical Cancer Research, February 24, 2026, Online ahead of print
E1218	K6PC-5	K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.	International Journal of Biological Sciences, April 18, 2022, 2994-3005 Cell Prolif, 2024, e13604. Int J Biol Sci, 2022, 18(7):2994-3005

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E2411

Taurodeoxycholic acid sodium hydrate

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. It activates S1PR2 pathway in addition to the TGR5 pathway.

S7791

PMA chemical (Phorbol 12-myristate 13-acetate)

PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way.

bioRxiv, March 14, 2026, Preprint

Scientific Reports, January 31, 2022, 1626

Clinical Cancer Research, February 24, 2026, Online ahead of print

E1218

K6PC-5

K6PC-5, a ceramide derivative, is a sphingosine kinase 1 (SPHK1) activator and elicits a rapid transient increase in intracellular calcium levels.

International Journal of Biological Sciences, April 18, 2022, 2994-3005

Cell Prolif, 2024, e13604.

Int J Biol Sci, 2022, 18(7):2994-3005