HIF Activators

Cat.No.	Product Name	Information	Product Use Citations
S5742	Deferoxamine mesylate	Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.	Exp Mol Med, 2026, 58(5):1479-1494 EMBO J, 2026, 45(4):1264-1291 Cell Death Discov, 2026, 12(1)167
S9490	Cobalt chloride	Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1α and AP-1 and iNOS signaling.Cobalt chloride can be used to induce animal models of High-altitude Polycythemia (HAPC).This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.	Journal of Translational Medicine, March 6, 2024, 245 Journal of Translational Medicine, March 06, 2024, 245 Research Square, February 13, 2026, nan
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Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S5742

Deferoxamine mesylate

Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilizes HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur.

Exp Mol Med, 2026, 58(5):1479-1494

EMBO J, 2026, 45(4):1264-1291

Cell Death Discov, 2026, 12(1)167

S9490

Cobalt chloride

Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. Cobalt chloride induces delayed cardiac preconditioning in mice through selective activation of HIF-1α and AP-1 and iNOS signaling.Cobalt chloride can be used to induce animal models of High-altitude Polycythemia (HAPC).This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Journal of Translational Medicine, March 6, 2024, 245

Journal of Translational Medicine, March 06, 2024, 245

Research Square, February 13, 2026, nan

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