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Hydroxylase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S4926 (R)-Nepicastat HCl (R)-Nepicastat HCl (RS-25560-198), the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
S6044 H-Tyr(3-I)-OH H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. This compound is an effective tyrosine hydroxylase inhibitor.
S3100 2-Thiouracil 2-Thiouracil (Deracil, Thiouracil) is a thiolated uracil derivative that is a known antihyperthyroid agent.
E7385New 1,4-DPCA 1,4‑DPCA is a competitive inhibitor of prolyl 4‑hydroxylase in embryonic chick tendon cells and of collagen hydroxylation in human foreskin fibroblasts, with IC50 values of 3.6 and 2.4 μM, respectively. β‑Oxocarboxylic acids such as 1,4‑DPCA also inhibit the asparaginyl‑hydroxylase factor inhibiting HIF (FIH), with an IC50 of 60 μM.
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. This compound has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
E2231 Xanthoangelol Xanthoangelol, a chalcone found in the roots of Angelica keiskei, is a nonselective monoamine oxidase (MAO) inhibitor and a potent dopamine β-hydroxylase (DBH) inhibitor. It has anti-inflammatory, antibiotic and pro-apoptotic activities.
Int J Biol Macromol, 2024, S0141-8130(24)09341-3