Synonyms: null
Enfortumab (Anti-Nectin-4) is a monoclonal antibody targeting Nectin-4 and has potential for research into urothelial cancer. MW: 145.44 kD.
| Featured Inhibitors | Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933 |
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| Description |
Enfortumab (Anti-Nectin-4) is a monoclonal antibody targeting Nectin-4 and has potential for research into urothelial cancer. MW: 145.44 kD.
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| CAS No. | 1448664-46-7 |
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| Molecular Weight | 145.44 kDa |
| Isotype | Human IgG1 |
| Source | CHO |
| Purification | AKTA |
| Sterility | 0.2 μM filtered |
| Formulation | 100 mM Pro-Ac, 20mM Arg, pH5.0 |
| Storage (From the date of receipt) |
Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT06764095 | RECRUITING | Drug: Enfortumab Vedotin | Locally Advanced Bladder Urothelial Carcinoma; Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma; Metastatic Bladder Urothelial Carcinoma; Metastatic Renal Pelvis and Ureter Urothelial Carcinoma; Stage III Bladder Cancer AJCC v8; Stage IV Bladder Cancer AJCC v8; Stage IV Renal Pelvis and Ureter Cancer AJCC v8 | Mayo Clinic | 2025-01-08 | PHASE4 |
| NCT07232602 | RECRUITING | Drug: MK-3120|Drug: EV|Drug: Rescue Medication | Bladder Cancer | Merck Sharp & Dohme LLC | 2026-02-09 | PHASE1; PHASE2 |
| NCT07663747 | NOT_YET_RECRUITING | Drug: Enfortumab Vedotin|Drug: Pembrolizumab | Urothelial Bladder Cancer | The Netherlands Cancer Institute | 2026-09-01 | PHASE2 |
| NCT07346053 | NOT_YET_RECRUITING | Drug: enfortumab vedotin and pembrolizumab (EV/P) | Advanced Bladder Cancer | Guliz Ozgun | 2026-05 | PHASE3 |
| NCT07720284 | RECRUITING | Drug: Dato-DXd|Drug: Rilvegostomig|Drug: Durvalumab|Drug: Ni | High-risk Muscle Invasive Urothelial Carcinoma | AstraZeneca | 2026-07-16 | PHASE3 |
| NCT03547973 | ACTIVE_NOT_RECRUITING | Drug: Sacituzumab Govitecan-hziy|Drug: Pembrolizumab|Drug: C | Metastatic Urothelial Cancer | Gilead Sciences | 2018-08-13 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-02-12)
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