PKC Inhibitors & Chemicals

Cat.No.	Product Name	Information	Product Citations
S1421	Staurosporine	Staurosporine (AM-2282) is a potent PKC inhibitor with IC50 of 2.7 nM.	PLoS One, 2012, 7(6), e39679 Am J Physiol Cell Physiol, 2013, ahead of print J Biomol Screen, 2012, 17(6):813-21
S2248	CX-4945 (Silmitasertib)	CX-4945 is a potent and selective inhibitor of CK2α and CK2α' with IC50 of 1 nM.	Biochim Biophys Acta, 2012, ahead of print
S2791	Sotrastaurin (AEB071)	Sotrastaurin (AEB071) is a potent selective pan-PKC inhibitor and highly inhibits PKCθ with K_i of 0.22 nM.	Am J Physiol Cell Physiol, 2013, ahead of print
S1055	Enzastaurin (LY317615)	Enzastaurin (LY317615) is a potent PKC inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively.	Cell, 2012, 149(3):656-70 Arthritis Rheum, 2012, ahead of print Oncogene, 2012, ahead of print
S2911	Go 6983	Go 6983 is a pan PKC inhibitor against PKCα, PKCβ, PKCγ, PKCδ, PKCζ with IC50 of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively.
S5002	Fingolimod (FTY720)	FTY720 (Fingolimod, Gilenya) is a S1P antagonist with IC50 of 0.033 nM.	Blood, 2012, 119(9):2176-7 PLoS One, 2012, 7(5):e36429 PLoS One, 2012, 7(2):e32211
S1314	Zoledronic Acid (Zoledronate)	A potent nitrogen-containing bisphosphonates.It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM.

Cat.No.	Product Name	Solubility (25°C)
Cat.No.	Product Name	Water	DMSO	Ethanol
S1421	Staurosporine	<1 mg/mL	4 mg/mL	<1 mg/mL
S2248	CX-4945 (Silmitasertib)	<1 mg/mL	16 mg/mL	<1 mg/mL
S2791	Sotrastaurin (AEB071)	<1 mg/mL	87 mg/mL	2 mg/mL
S1055	Enzastaurin (LY317615)	<1 mg/mL	30 mg/mL	<1 mg/mL
S2911	Go 6983	<1 mg/mL	59 mg/mL	<1 mg/mL
S5002	Fingolimod (FTY720)	69 mg/mL	69 mg/mL	69 mg/mL
S1314	Zoledronic Acid (Zoledronate)	4 mg/mL	<1 mg/mL	<1 mg/mL

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