New STAT Inhibitors

Catalog No.	Product Name	Information
E5937	AK-1690	AK‑1690 is a selective PROTAC degrader of STAT6 (DC50 ≈ 1 nM) that recruits STAT6 to cereblon, inducing its ubiquitin‑dependent proteasomal degradation in cells and tissues.
E6670	AC-4-130	AC-4–130 is a potent, selective inhibitor of the STAT5 SH2 domain that directly binds to STAT5, blocking its phosphorylation, dimerization, and nuclear translocation. It acts by disrupting STAT5-dependent gene transcription, effectively reducing pathological STAT5 activity in acute myeloid leukemia (AML).
E6675	MC3482	MC3482 is a specific, cell-permeable inhibitor of SIRT5 that mitigates microglia-induced neuroinflammation and neuronal apoptosis by regulating Annexin-A1 succinylation. It significantly improves long-term sensorimotor and cognitive function, exhibiting potential for anti-ischemic stroke treatment.
E6626	STAT3-IN-3	STAT3-IN-3 is a potent, selective chemical inhibitor of Signal Transducer and Activator of Transcription 3 (STAT3) that has shown efficacy in mitigating drug resistance.
F0451	Phospho-STAT1 (Ser727) Antibody [K4E23]	Phospho-Stat1 (Ser727),STAT1 (phospho S727)
≡ All STAT Inhibitors