| S9814 |
BMS-986202 |
BMS‑986202 is a potent, selective and orally active inhibitor of TYK2 that binds to the TYK2 pseudokinase domain (JH2) with an IC50 of 0.19 nM and a Ki of 0.02 nM. |
| S3521 |
Golidocitinib(AZD4205) |
Golidocitinib (AZD4205) (Compound 21) is a highly selective and potent inhibitor of Janus kinase 1 (JAK1), with an IC50 of 0.07 μM for JAK1 and much weaker inhibition of JAK2 (IC50 > 15 μM). It also exhibits potent antitumor effects in NSCLC xenograft models in preclinical studies. |
| F2644 |
Phospho-JAK1 (Tyr1034/1035)/JAK2 (Tyr1007/1008) Antibody [L3G19] |
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| E5866 |
Cenacitinib |
Cenacitinib is an orally potent and selective allosteric inhibitor of tyrosine kinase 2 (Tyk2). It exhibits significant efficacy and can be used in research for the treatment of moderate to severe psoriasis. |