SMILES:

C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O
Zoledronic acid monohydrate Chemical Structure
Chemical Structure
Check the Zoledronic acid monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 165800-06-6
Molecular Formula

C5H10N2O7P2.H2O
Molecular Weight (MW) 290.1
SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
0.5MNAOH 6.02 mg/mL
Water 2.3 mg/mL
DMSO 0.01 mg/mL (0.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.