CAS No. 165800-06-6
Batch:
Purity:98
Chemical Structure
Check the
Zoledronic acid monohydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 165800-06-6 | |
|---|---|---|
| Molecular Formula |
C5H10N2O7P2.H2O |
|
| Molecular Weight (MW) | 290.1 | |
| SMILES | C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O |
Zoledronic acid monohydrate is a nitrogen-containing bisphosphonate and potent osteoclast inhibitor. It suppresses the mevalonate pathway by inhibiting key enzymes such as farnesyl pyrophosphate synthase, thereby disrupting the isoprenylation of small GTP-binding proteins including Ras and Rho. This impairment of essential signaling cascades inhibits osteoclast survival and function, ultimately inducing osteoclast apoptosis and preventing bone resorption. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 0.5MNAOH | 6.02 mg/mL |
| Water | 2.3 mg/mL |
| DMSO |
0.01 mg/mL
(0.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Zoledronic acid monohydrate Clinical Trials
- Zoledronic acid monohydrate Solubility in DMSO
- Zoledronic acid monohydrate Stock Solution
- Zoledronic acid monohydrate Storage
- Zoledronic acid monohydrate Stability
- Zoledronic acid monohydrate Molecular Weight
- Zoledronic acid monohydrate SMILES
- Zoledronic acid monohydrate Chemical Structure (2D and 3D)
- Zoledronic acid monohydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.