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Ziftomenib (KO-539) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Ziftomenib (KO-539)
  • Catalog Number: E1290
  • CAS Number: 2134675-36-6
  • IUPAC Name: 1H -Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2- trifluoroethyl)thieno[2,3-d ]pyrimidin-4-yl]amino]-1-piperidinyl] methyl]-1-[(2S )-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

The substance is not classified as hazardous according to the Globally Harmonized System (GHS).

Label elements:

  • GHS label elements: None
  • Signal word: None
  • Hazard statements: None

Classification system:

  • NFPA ratings (scale 0 - 4): Health = 0, Fire = 0, Reactivity = 0.
  • HMIS-ratings (scale 0 - 4): Health = 0, Fire = 0, Physical Hazard = 0.

Other hazards:

  • Results of PBT and vPvB assessment: Not applicable.
  • Hazards not otherwise classified: There are no adverse physical or health effects known that are not covered by the Hazard Communications Standard.

3. Composition/information on ingredients

Chemical characterization: Substances
Description: 1H -Indole-2-carbonitrile, 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2- trifluoroethyl)thieno[2,3-d ]pyrimidin-4-yl]amino]-1-piperidinyl] methyl]-1-[(2S )-2-[4-(methylsulfonyl)-1-piperazinyl]propyl]-
CAS No. Description: Ziftomenib

4. First-aid measures

Description of first aid measures:

  • General information: No special measures required.
  • After inhalation: Supply fresh air; consult a doctor in case of complaints.
  • After skin contact: Generally, the product does not irritate the skin.
  • After eye contact: Rinse the opened eye for several minutes under running water.
  • After swallowing: If symptoms persist, consult a doctor.

Most important symptoms and effects, both acute and delayed: No further relevant information available.

Indication of any immediate medical attention and special treatment needed: No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

  • Suitable extinguishing agents: Use fire-fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture: No further relevant information available.

Advice for firefighters:

  • Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures: Not required.

Environmental precautions: Do not allow to enter sewers, surface, or ground water.

Methods and material for containment and cleaning up: Pick up mechanically.

Protective Action Criteria for Chemicals:

  • PAC-1: Substance is not listed.
  • PAC-2: Substance is not listed.
  • PAC-3: Substance is not listed.

Reference to other sections:

  • See Section 7 for information on safe handling.
  • See Section 8 for information on personal protection equipment.
  • See Section 13 for disposal information.

7. Handling and storage

Precautions for safe handling: No special measures required.
Information about protection against explosions and fires: No special measures required.

Conditions for safe storage, including any incompatibilities:

  • Storage: Store in accordance with information listed on the product insert.
  • Requirements to be met by storerooms and receptacles: No special requirements.
  • Information about storage in one common storage facility: Not required.
  • Further information about storage conditions: None.

Specific end use(s): No further relevant information available.

8. Exposure controls/personal protection

Control parameters:

  • Components with limit values that require monitoring at the workplace: Not required.
  • Additional information: The lists that were valid during the creation were used as a basis.

Exposure controls:

  • Appropriate engineering controls: No further data; see section 7.
  • Personal protective equipment:
    • General protective and hygienic measures: The usual precautionary measures for handling chemicals should be followed.
    • Breathing equipment: Not required.
    • Protection of hands: The glove material has to be impermeable and resistant to the product/the substance/the preparation. Due to missing tests, no recommendation to the glove material can be given. Selection of the glove material should consider penetration times, rates of diffusion, and degradation.
    • Material of gloves: The selection of suitable gloves depends not only on the material but also on further marks of quality and varies from manufacturer to manufacturer.
    • Penetration time of glove material: The exact break-through time has to be determined by the manufacturer of the protective gloves and must be observed.
    • Eye protection: Not required.

9. Physical and chemical properties

Information on basic physical and chemical properties:

  • Physical state: powder
  • Color: Not determined.
  • Odor: Characteristic
  • Structural Formula: C33H42F3N9O2S2
  • Molecular Weight: 717.9 g/mol
  • Odor threshold: Not determined.
  • Melting point/Melting range: Undetermined.
  • Boiling point/Boiling range: Undetermined.
  • Flammability: Product is not flammable.
  • Explosion limits: Lower: Not determined; Upper: Not determined.
  • Flash point: Not applicable.
  • Decomposition temperature: Not determined.
  • pH-value: Not applicable.
  • Viscosity (Kinematic/Dynamic): Not applicable.
  • Solubility in / Miscibility with Water: Not determined.
  • Partition coefficient (n-octanol/water): Not determined.
  • Vapor pressure: Not applicable.
  • Density: Not determined.
  • Relative density: Not determined.
  • Vapor density: Not applicable.
  • Particle characteristics: Not determined.
  • Appearance (Form): powder
  • Ignition temperature: Not determined.
  • Danger of explosion: Product does not present an explosion hazard.
  • Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity: No further relevant information available.

Chemical stability:

  • Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.

Possibility of hazardous reactions: No dangerous reactions known.

Conditions to avoid: No further relevant information available.

Incompatible materials: No further relevant information available.

Hazardous decomposition products: No dangerous decomposition products known.

11. Toxicological information

Information on toxicological effects:

  • Acute toxicity: Based on available data, the classification criteria are not met.
  • Primary irritant effect:
    • On the skin: No irritant effect.
    • On the eye: No irritating effect.
  • Sensitization: No sensitizing effects known.
  • Additional toxicological information: When used and handled according to specifications, the product does not have any harmful effects according to our experience and the information provided. The substance is not subject to classification.
  • Interactive effects: No interactive effects between components are known.
  • Carcinogenic categories:
    • IARC (International Agency for Research on Cancer): Substance is not listed.
    • NTP (National Toxicology Program): Substance is not listed.
    • OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

12. Ecological information

Toxicity:

  • Aquatic toxicity: No further relevant information available.

Persistence and degradability: No further relevant information available.

Bioaccumulative potential: No further relevant information available.

Mobility in soil: No further relevant information available.

Results of PBT and vPvB assessment: Not applicable.

Other adverse effects:

  • General notes: Water hazard class 1 (Self-assessment): slightly hazardous for water. Do not allow undiluted product or large quantities of it to reach ground water, water course, or sewage system.

13. Disposal considerations

Waste treatment methods:

  • Recommendation: Smaller quantities can be disposed of with household waste.

Uncleaned packagings:

  • Recommendation: Disposal must be made according to official regulations.

14. Transport information

  • UN-Number (DOT, IMDG, IATA): Not regulated
  • UN proper shipping name (DOT, IMDG, IATA): Not regulated
  • Transport hazard class(es) (DOT, ADN, IMDG, IATA): Not regulated
  • Packing group (DOT, IMDG, IATA): Not regulated
  • Environmental hazards: Not applicable.
  • Special precautions for user: Not applicable.
  • Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code: Not applicable.
  • UN "Model Regulation": Not regulated

15. Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture:
No further relevant information available.

Sara:

  • Section 355 (extremely hazardous substances): Substance is not listed.
  • Section 313 (Specific toxic chemical listings): Substance is not listed.
  • TSCA (Toxic Substances Control Act): Substance is not listed.
  • Hazardous Air Pollutants: Substance is not listed.

Proposition 65:

  • Chemicals known to cause cancer: Substance is not listed.
  • Chemicals known to cause reproductive toxicity for females: Substance is not listed.
  • Chemicals known to cause reproductive toxicity for males: Substance is not listed.
  • Chemicals known to cause developmental toxicity: Substance is not listed.

Carcinogenic categories:

  • EPA (Environmental Protection Agency): Substance is not listed.
  • TLV (Threshold Limit Value): Substance is not listed.
  • NIOSH-Ca (National Institute for Occupational Safety and Health): Substance is not listed.

Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16. OTHER INFORMATION

Revision Date: 2026/07/14
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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