CAS No. 2134675-36-6
Batch:
Purity:99.88
Chemical Structure
Check the
Ziftomenib (KO-539)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1-[(2S)-2-(4-methylsulfonylpiperazin-1-yl)propyl]indole-2-carbonitrile | |
|---|---|---|
| CAS Number | 2134675-36-6 | |
| Molecular Formula |
C33H42F3N9O2S2 |
|
| Molecular Weight (MW) | 717.87 | |
| InChIKey | BGGALFIXXQOTPY-NRFANRHFSA-N |
Ziftomenib (KO- is an oral small molecule menin inhibitor targeting the menin–KMT2A protein interaction. Disruption of the menin–KMT2A chromatin complex suppresses leukemogenic target gene expression, which downstream leads to the inhibition of cell proliferation, induction of myeloid differentiation, and stimulation of apoptosis in acute myeloid leukemia cells expressing KMT2A rearrangements or mutant NPM1. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(139.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(139.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 33 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(139.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(139.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(139.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Ziftomenib (KO-539) Mechanism of Action: Menin Inhibition in Leukemic Blasts Research
- Ziftomenib (KO-539) Clinical Trials
- Ziftomenib (KO-539) Solubility in DMSO
- Ziftomenib (KO-539) Stock Solution
- Ziftomenib (KO-539) Storage
- Ziftomenib (KO-539) Stability
- Ziftomenib (KO-539) Molecular Weight
- Ziftomenib (KO-539) Chemical Structure (2D and 3D)
- Ziftomenib (KO-539) MedChemExpress (HY-132001)? Try a better option.
- Ziftomenib (KO-539) Sigma (TA9H98DCB3CD)? Try a better option.
- Ziftomenib (KO-539) Cayman (45139)? Try a better option.
- Ziftomenib (KO-539) Abmole (M13430)? Try a better option.
- Ziftomenib (KO-539) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.