CAS No. 139110-80-8

Batch: Purity:99.97
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Zanamivir Chemical Structure
Chemical Structure
Check the Zanamivir product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
CAS Number 139110-80-8
Molecular Formula

C12H20N4O7
Molecular Weight (MW) 332.31
SMILES CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
InChIKey ARAIBEBZBOPLMB-UFGQHTETSA-N

Ordering Information

Biological Activity

Zanamivir is a potent neuraminidase inhibitor that selectively targets viral neuraminidase (sialidase) enzymes. By binding to the conserved active site of influenza neuraminidase, it prevents the cleavage of terminal sialic acid residues on cell-surface glycoconjugates. This inhibition blocks the release of newly formed progeny virions from infected host cells, thereby suppressing viral replication and spread of both influenza A and influenza B strains. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 25 mg/mL
DMSO 2 mg/mL (6.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.