CAS No. 19545-26-7

Batch: Purity:99.97
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Wortmannin (SL-2052) Chemical Structure
Chemical Structure
Check the Wortmannin (SL-2052) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
CAS Number 19545-26-7
Molecular Formula

C23H24O8
Molecular Weight (MW) 428.43
SMILES CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
InChIKey QDLHCMPXEPAAMD-QAIWCSMKSA-N

Ordering Information

Biological Activity

Wortmannin is a potent, covalent phosphoinositide 3-kinase (PI3K) inhibitor that suppresses phosphatidylinositol 3,4,5-trisphosphate production with an IC50 ofin intact cells. By disrupting the PI3K/AKT signaling axis, wortmannin inhibits downstream effector activation and cytoskeletal rearrangements. These targeted pathway disruptions result in the inhibition of autophagosome formation, suppression of cell proliferation, and impairment of agonist-induced neutrophil respiratory burst responses. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (198.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.