VVD-214 (VVD-133214, RO7589831) is a targeted WRN inhibitor. It affects mismatch repair (MMR) and KMT2D-associated signaling, by inhibiting WRN function, effectively suppressing the proliferation of microsatellite instability (MSI) colorectal cancer cells harboring KMT2D loss-of-function mutations.
VVD-214 (VVD-133214, RO7589831) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for VVD-214 (VVD-133214, RO7589831) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.