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PLX4032 (Vemurafenib) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: PLX4032 (Vemurafenib)
  • Catalog Number: S1267
  • CAS Number: 918504-65-1
  • IUPAC Name: N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

Pictogram: GHS09

Classification of the substance or mixture:
Aquatic Chronic 1 H410: Very toxic to aquatic life with long lasting effects.

Label elements:
The substance is classified and labeled according to the Globally Harmonized System (GHS).

Signal word: Warning

Hazard statements:
H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements:

  • P273: Avoid release to the environment.
  • P391: Collect spillage.
  • P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification system:

  • NFPA ratings (scale 0 - 4): Health = 0, Fire = 0, Reactivity = 0.
  • HMIS-ratings (scale 0 - 4): Health = 0, Fire = 0, Reactivity = 0.

Other hazards:

  • Results of PBT and vPvB assessment: Not applicable.
  • Hazards not otherwise classified: There are no adverse physical or health effects known that are not covered by the hazard classes of the Hazard Communications Standard.

3. Composition/information on ingredients

Chemical characterization: Substances
CAS No. Description: 918504-65-1 PLX4032

4. First-aid measures

Description of first aid measures:

  • After inhalation: Supply fresh air; consult doctor in case of complaints.
  • After skin contact: Generally the product does not irritate the skin.
  • After eye contact: Rinse opened eye for several minutes under running water.
  • After swallowing: If symptoms persist consult doctor.

Most important symptoms and effects, both acute and delayed:
No further relevant information available.

Indication of any immediate medical attention and special treatment needed:
No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

  • Suitable extinguishing agents: Use fire fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture:
No further relevant information available.

Advice for firefighters:

  • Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures: Not required.

Environmental precautions:
Inform respective authorities in case of seepage into water course or sewage system. Do not allow to enter sewers/ surface or ground water.

Methods and material for containment and cleaning up:
Pick up mechanically.

Reference to other sections:

  • See Section 7 for information on safe handling.
  • See Section 8 for information on personal protection equipment.
  • See Section 13 for disposal information.

7. Handling and storage

Precautions for safe handling:
No special precautions are necessary if used correctly. Avoid breathing powder/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep away from sources of ignition. Take precautionary measures against static discharge.

Information about protection against explosions and fires: No special measures required.

Conditions for safe storage, including any incompatibilities:

  • Storage: Store in accordance with information listed on the product insert.
  • Requirements to be met by storerooms and receptacles: No special requirements.
  • Information about storage in one common storage facility: Not required.
  • Further information about storage conditions: None.

Specific end use(s): No further relevant information available.

8. Exposure controls/personal protection

Control parameters:

  • Components with limit values that require monitoring at the workplace: Not required.

Appropriate engineering controls: No further data; see section 7.

Personal protective equipment:

  • General protective and hygienic measures: Wash hands before breaks and at the end of work.
  • Breathing equipment: Not required.
  • Protection of hands: The glove material has to be impermeable and resistant to the product. Selection of the glove material should consider penetration times, rates of diffusion, and degradation.
  • Material of gloves: The selection of suitable gloves depends on the material and quality marks, varying from manufacturer to manufacturer.
  • Penetration time of glove material: The exact break through time must be determined by the manufacturer and observed.
  • Eye protection: Not required.

9. Physical and chemical properties

Information on basic physical and chemical properties:

  • Physical state: powder
  • Color: Not determined.
  • Odor: Characteristic
  • Structural Formula: C23H18ClF2N3O3S
  • Molecular Weight: 489.9 g/mol
  • Odor threshold: Not determined.
  • Melting point/Melting range: 272 °C (521.6 °F)
  • Boiling point/Boiling range: Undetermined.
  • Flammability: Product is not flammable.
  • Explosion limits: Lower: Not determined; Upper: Not determined.
  • Flash point: Not applicable.
  • Decomposition temperature: Not determined.
  • pH-value: Not applicable.
  • Viscosity (Kinematic/Dynamic): Not applicable.
  • Solubility: DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 1 mg/ml.
  • Water Solubility: Not determined.
  • Partition coefficient (n-octanol/water): Not determined.
  • Vapor pressure: Not applicable.
  • Density: Not determined.
  • Relative density: Not determined.
  • Vapor density: Not applicable.
  • Particle characteristics: Not determined.
  • Appearance Form: powder
  • Ignition temperature: Not determined.
  • Danger of explosion: Product does not present an explosion hazard.
  • Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity: No further relevant information available.

Chemical stability:

  • Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.

Possibility of hazardous reactions: No dangerous reactions known.

Conditions to avoid: No further relevant information available.

Incompatible materials: strong oxidizing agents

Hazardous decomposition products: carbon dioxide, carbon monoxide, hydrogen fluoride, hydrogen sulfide, nitrogen oxides, phosgene.

11. Toxicological information

RTECS Number: TZ6080500

Information on toxicological effects:

  • Acute toxicity: No specific data provided.
  • Primary irritant effect (Skin/Eye): No irritant or irritating effect.
  • Sensitization: No sensitizing effects known.
  • Interactive effects: No interactive effects between components are known.

Carcinogenic categories:

  • IARC (International Agency for Research on Cancer): Substance is not listed.
  • NTP (National Toxicology Program): Substance is not listed.
  • OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

12. Ecological information

Toxicity:

  • Aquatic toxicity: No further relevant information available.

Persistence and degradability: No further relevant information available.

Bioaccumulative potential: No further relevant information available.

Mobility in soil: No further relevant information available.

Results of PBT and vPvB assessment: Not applicable.

Other adverse effects:

  • General notes: Water hazard class 2 (Self-assessment): hazardous for water. Do not allow product to reach ground water, water course, or sewage system. Danger to drinking water if even small quantities leak into the ground. Also poisonous for fish and plankton in water bodies.

13. Disposal considerations

Waste treatment methods:

  • Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings:

  • Recommendation: Disposal must be made according to official regulations.

14. Transport information

UN-Number:

  • DOT, IMDG, IATA: UN3077

UN proper shipping name:

  • DOT, IATA: Environmentally hazardous substance, powder, n.o.s. (PLX4032)
  • IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, POWDER, N.O.S. (PLX4032)

Transport hazard class(es):

  • DOT, IMDG, IATA Class: 9 Miscellaneous dangerous substances and articles
  • Label: 9

Packing group:

  • DOT, IMDG, IATA: III

Environmental hazards:

  • Marine pollutant: Symbol (fish and tree)
  • Special marking (IATA): Symbol (fish and tree)

Special precautions for user: Warning: Miscellaneous dangerous substances and articles

  • Hazard identification number (Kemler code): 90
  • EMS Number: F-A, S-F
  • Stowage Category: A
  • Stowage Code: SW23 When transported in BK3 bulk container, see 7.6.2.12 and 7.7.3.9.

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code: Not applicable.

Transport/Additional information:

  • DOT Quantity limitations: On passenger aircraft/rail: 400 kg; On cargo aircraft only: 400 kg.
  • IMDG Limited quantities (LQ): 5 kg
  • IMDG Excepted quantities (EQ): Code: E1 (Max net quantity per inner packaging: 30 g; Max net quantity per outer packaging: 1000 g).
  • IATA Remarks: When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of E1, E2, E4, or E5, this item meets the De Minimis Quantities exemption, per IATA 2.6.10.

UN "Model Regulation": UN 3077 ENVIRONMENTALLY HAZARDOUS SUBSTANCE, POWDER, N.O.S. (PLX4032), 9, III

15. Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture
No further relevant information available.
· Sara
· Section 355 (extremely hazardous substances):Substance is not listed.
· Section 313 (Specific toxic chemical listings):Substance is not listed.
· TSCA (Toxic Substances Control Act):Substance is not listed.
· Hazardous Air PollutantsSubstance is not listed.
· Chemicals known to cause cancer:Substance is not listed.
· Chemicals known to cause reproductive toxicity for females:Substance is not listed.
· Chemicals known to cause reproductive toxicity for males:Substance is not listed.
· Chemicals known to cause developmental toxicity:Substance is not listed.
· Carcinogenic categories
· EPA (Environmental Protection Agency)Substance is not listed.
· TLV (Threshold Limit Value)Substance is not listed.
· NIOSH-Ca (National Institute for Occupational Safety and Health)Substance is not listed.
· Chemical safety assessment:A Chemical Safety Assessment has not been carried out.

16. OTHER INFORMATION

Revision Date: 2026/07/07
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

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