Vemurafenib is a potent and selective BRAFV600E kinase inhibitor. It affects the MAPK/ERK signaling pathway by blocking MEK and ERK phosphorylation, effectively inhibiting cell proliferation and migration, and inducing apoptosis in BRAF-mutated cancer cells.
PLX4032 (Vemurafenib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for PLX4032 (Vemurafenib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.