CAS No. 1809336-39-7
| IUPAC Name | (2R)-7-chloro-2-[4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide | |
|---|---|---|
| CAS Number | 1809336-39-7 | |
| Molecular Formula |
C26H34ClN3O4
|
|
| Molecular Weight (MW) | 488.02 | |
| SMILES | CC1=CC(=C(C(=O)N1)CNC(=O)C2=CC(=C3C(=C2C)OC(O3)(C)C4CCC(CC4)N(C)C)Cl)C | |
| InChIKey | SSDRNUPMYCFXGM-ZZHSESOFSA-N |
Valemetostat (DS-3201) is a selective dual inhibitor of enhancer of zeste homolog 1 (EZH1) and EZH2. By blocking EZH1 and EZH2 catalytic activity, Valemetostat decreases global histone H3 lysine 27 trimethylation (H3K27me3) levels and disrupts polycomb repressive complex 2 (PRC2)-mediated transcriptional repression. This inhibition leads to the reactivation of silenced tumor suppressor genes, resulting in cell cycle arrest, inhibition of cell proliferation, and induction of apoptosis in hematological malignancy models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 98 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(204.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 49 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Valemetostat (DS-3201) Mechanism of Action: EZH2 Inhibition in T-cell Research
- Valemetostat (DS-3201) Clinical Trials
- Valemetostat (DS-3201): Selectivity & Specificity
- Valemetostat (DS-3201) Working Concentration | Cell Culture | Treatment
- Valemetostat (DS-3201) Solubility in DMSO
- Valemetostat (DS-3201) Stock Solution
- Valemetostat (DS-3201) Storage
- Valemetostat (DS-3201) Stability
- Valemetostat (DS-3201) Combination Database
- Valemetostat (DS-3201) Molecular Weight
- Valemetostat (DS-3201) SMILES
- Valemetostat (DS-3201) Chemical Structure (2D and 3D)
- Valemetostat (DS-3201) IC50 for Cell-based and Cell-free Assays
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- Valemetostat (DS-3201) SDS｜MSDS