CAS No. 38748-32-2
Batch:
Purity:99.58
Chemical Structure
Check the
Triptolide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one | |
|---|---|---|
| CAS Number | 38748-32-2 | |
| Molecular Formula |
C20H24O6 |
|
| Molecular Weight (MW) | 360.4 | |
| InChIKey | DFBIRQPKNDILPW-CIVMWXNOSA-N |
Triptolide is a diterpene triepoxide natural product and immunosuppressive agent that targets the NF-kB and heat shock transcription factor 1 (HSF1) signaling pathways. It inhibits NF-kB activation by disrupting the p65/CBP interaction and reducing p65 protein levels, while abrogating HSF1 transactivation. Downstream, triptolide suppresses MDM2 expression and induces apoptosis through a p53-independent pathway to inhibit cellular proliferation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Triptolide Mechanism of Action: XPB Inhibition in Cancer Cell Research
- Triptolide Clinical Trials
- Triptolide Working Concentration | Cell Culture | Treatment
- Triptolide Solubility in DMSO
- Triptolide Stock Solution
- Triptolide Storage
- Triptolide Stability
- Triptolide Combination Database
- Triptolide Molecular Weight
- Triptolide Chemical Structure (2D and 3D)
- Triptolide IC50 for Cell-based and Cell-free Assays
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- Triptolide SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.