CAS No. 440-17-5

Batch: Purity:99.99
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Trifluoperazine 2HCl Chemical Structure
Chemical Structure
Check the Trifluoperazine 2HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride
CAS Number 440-17-5
Molecular Formula

C21H24F3N3S.2HCl
Molecular Weight (MW) 480.42
SMILES CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl
InChIKey BXDAOUXDMHXPDI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Trifluoperazine 2HCl is a potent dopamine D2 receptor inhibitor (IC50 1.1 nM) that also inhibits calmodulin (CaM). By disrupting dopamine D2 receptor signaling and inhibiting calmodulin activity, it alters intracellular calcium regulation and modulates downstream signaling cascades. These molecular effects lead to impaired dopaminergic neurotransmission and suppressed cell proliferation across multiple tumor cell models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 96 mg/mL
Ethanol 96 mg/mL
DMSO 88 mg/mL (183.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.