For research use only. Not for use in humans.

Tomaralimab (Anti-TLR2 / CD282)

Synonyms: OPN-305 Cat.No.A2333 Purity:99%

Tomaralimab (Anti-TLR2 / CD282) is a humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2) with potential anti-inflammatory and antineoplastic activities. It has the potential for research on Myelodysplastic Syndromes (MDS). MW : 145.5 KD.

Quality Control

Batch: A233301 Purity: 99% Protein concentration: 4.731mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	TLR7	TLR8	TLR9	TLR4	TLR2	TLR3	TLR1	Others
Enpatoran Hydrochloride	0	++++	+++
CU-CPT-8m	1		+++
CU-CPT9a	2		++++
MD2-IN-1	3				+
CU-CPT22	9					++		++
Okanin	0				✔				NF-κB
AMG-9810	1					✔			hTRPV1,rTRPV1
TLR4-IN-C34	7				✔
E6446	5	✔							DNA-TLR9
TLR2-IN-C29	21					✔
MD2-TLR4-IN-1	0				✔				IL-6,TNF-α
IAXO-102	0				✔				NF-κB,MAPK
E6446 Dihydrochloride	4			✔
Resatorvid (TAK-242)	63				✔				IL-6,NO,TNF-α
Ginsenoside Rb1	4						✔		IFN-β,TNF-α,NF-κB

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Tomaralimab (Anti-TLR2 / CD282) is a humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2) with potential anti-inflammatory and antineoplastic activities. It has the potential for research on Myelodysplastic Syndromes (MDS). MW : 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1449294-76-1
Molecular Weight	145.5 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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