Numerous clinical trials spanning Early Phase 1 through Phase 3 have extensively evaluated Thiotepa in combined conditioning and therapeutic regimens across primary CNS lymphoma, acute leukemias, solid tumors, breast cancer, and non-malignant disorders such as Fanconi anemia. Sponsored by prominent academic and medical research institutions—including St. Jude Children's Research Hospital, the University of California San Francisco, and M.D. Anderson Cancer Center—these investigations encompass diverse recruitment statuses, ranging from completed and active not recruiting to currently recruiting.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT07616154 | RECRUITING | Sickle Cell Disease |
St. Jude Children's Research Hospital |
2026-09 | PHASE2 |
| NCT05565105 | NOT_YET_RECRUITING | Leukemia, Myeloid, Acute; Leukemia, Lymphocytic, Acute |
Guenther Koehne |
2026-06 | PHASE2 |
| NCT07759102 | NOT_YET_RECRUITING | Recurrent Multiple Myeloma; Refractory Multiple Myeloma |
University of California, Davis |
2026-09-01 | PHASE1 |
| NCT07257419 | RECRUITING | Relapsed Pediatric ALL; Hematopoietic Cell Transplantation; Hematologic Malignancy |
St. Jude Children's Research Hospital |
2026-10-03 | PHASE1 |
| NCT06013423 | RECRUITING | Acute Leukemia of Ambiguous Lineage; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Blastic Plasmacytoid Dendritic Cell Neoplasm; Hematopoietic and Lymphatic System Neoplasm; Mixed Phenotype Acute Leukemia; Myelodysplastic Syndrome; Myeloproliferative Neoplasm; Non-Hodgkin Lymphoma; Chronic Myeloid Leukemia, BCR-ABL1 Positive |
Fred Hutchinson Cancer Center |
2024-07-23 | PHASE2 |
| NCT02870907 | ACTIVE_NOT_RECRUITING | Retinoblastoma |
Institut Curie |
2010-03-18 | PHASE2 |
| NCT06942039 | RECRUITING | CNS Embryonal Tumor; CNS, Medulloblastoma; Atypical Teratoid Rhabdoid Tumor; Medulloblastoma, Childhood; Medulloblastoma, Group 3; Medulloblastoma, Group 4; Pineoblastoma; Neuroblastoma; Embryonal Tumor With Multilayered Rosettes; Embryonal Tumor With Abundant Neuropil and True Rosettes; Ependymoblastoma; Medulloepithelioma; CNS Embryonal Tumor With Rhabdoid Features; CNS Embryonal Tumor, Nos |
C17 Council |
2025-09-23 | EARLY_PHASE1 |
| NCT03126916 | RECRUITING | Ganglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma |
Children's Oncology Group |
2018-05-14 | PHASE3 |
| NCT01949129 | RECRUITING | Acute Lymphoblastic Leukaemia |
St. Anna Kinderkrebsforschung |
2013-04 | PHASE2; PHASE3 |
| NCT07566377 | RECRUITING | Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndromes; Non-hodgkin Lymphoma; Hodgkin Lymphoma; Leukemia; Lymphoma; Graft-versus-host Disease |
Memorial Sloan Kettering Cancer Center |
2026-04-28 | PHASE2 |
| NCT06195891 | RECRUITING | Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome |
City of Hope Medical Center |
2024-05-24 | PHASE1 |
| NCT04282174 | WITHDRAWN | Hematologic Diseases; Hematologic Malignancy; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Myelogenous Leukemia; Chronic Lymphocytic Leukemia |
Baptist Health South Florida |
2022-09 | PHASE2 |
| NCT07074470 | RECRUITING | Primary Central Nervous System Lymphoma (PCNSL) |
The First Affiliated Hospital of Soochow University |
2025-01-02 | |
| NCT06172296 | RECRUITING | Ganglioneuroblastoma, Nodular; Neuroblastoma |
National Cancer Institute (NCI) |
2024-04-19 | PHASE3 |
| NCT07276737 | NOT_YET_RECRUITING | NK T-Cell Lymphoma |
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine |
2025-12-30 | PHASE2 |
| NCT04684368 | RECRUITING | Central Nervous System Nongerminomatous Germ Cell Tumor; Choriocarcinoma; Embryonal Carcinoma; Immature Teratoma; Malignant Teratoma; Mixed Germ Cell Tumor; Pineal Region Germ Cell Tumor; Pineal Region Immature Teratoma; Pineal Region Yolk Sac Tumor; Suprasellar Germ Cell Tumor |
Children's Oncology Group |
2021-07-13 | PHASE2 |
| NCT07259161 | NOT_YET_RECRUITING | CML,Blast Phase; HSCT |
Institute of Hematology & Blood Diseases Hospital, China |
2025-12-15 | PHASE2 |
| NCT07565220 | RECRUITING | Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Acute Leukemia; Myelodysplastic Syndrome(MDS); Myeloproliferative Neoplasm (MPN) |
Sawa Ito, MD |
2026-07-27 | PHASE1 |
| NCT07563920 | NOT_YET_RECRUITING | Acute Myeloid Leukemia |
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine |
2026-06 | |
| NCT03779854 | ACTIVE_NOT_RECRUITING | Acute Biphenotypic Leukemia; Acute Leukemia; Acute Leukemia of Ambiguous Lineage; Acute Lymphoblastic Leukemia; Acute Undifferentiated Leukemia; Allogeneic Hematopoietic Stem Cell Transplantation Recipient; Blastic Plasmacytoid Dendritic Cell Neoplasm; Blasts Under 25 Percent of Bone Marrow Nucleated Cells; Blasts Under 5 Percent of Bone Marrow Nucleated Cells; Mixed Phenotype Acute Leukemia; Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome/Acute Myeloid Leukemia; Burkitt Leukemia; Chronic Monocytic Leukemia; Lymphoblastic Lymphoma; Mast Cell Leukemia; Myeloproliferative Neoplasm |
Fred Hutchinson Cancer Center |
2019-08-29 | PHASE2 |
| NCT07052370 | RECRUITING | Hematologic Malignancy |
St. Jude Children's Research Hospital |
2025-09-25 | PHASE1 |
| NCT06158828 | RECRUITING | AML, Childhood; Aml; Acute Myeloid Leukemia, Pediatric; Acute Myeloid Leukemia |
Washington University School of Medicine |
2024-11-15 | PHASE1; PHASE2 |
| NCT02861417 | ACTIVE_NOT_RECRUITING | Hematopoietic and Lymphoid Cell Neoplasm; High Risk Acute Myeloid Leukemia; High Risk Myelodysplastic Syndrome; Lymphoproliferative Disorder; Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent High Risk Myelodysplastic Syndrome; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma |
M.D. Anderson Cancer Center |
2016-08-05 | PHASE2 |
| NCT04678401 | RECRUITING | Stem Cell Transplant Complications; Graft Vs Host Disease; Myeloid Leukemia, Acute; Myeloid Leukemia in Relapse (Disorder); Myelodysplastic Syndromes |
Dana-Farber Cancer Institute |
2021-01-12 | PHASE1 |
| NCT07416890 | RECRUITING | Pirtobrutinib; Sintilimab; Central Nervous System Lymphoma |
Zhejiang Cancer Hospital |
2026-02-10 | PHASE2 |
| NCT03630211 | RECRUITING | Systemic Sclerosis; Diffuse Sclerosis Systemic; Interstitial Lung Disease; Pulmonary Hypertension |
Paul Szabolcs |
2018-07-31 | PHASE2 |
| NCT03653338 | RECRUITING | Sickle Cell Anemia; Beta-thalassemia Major; Diamond-blackfan Anemia |
Paul Szabolcs |
2018-08-02 | PHASE1; PHASE2 |
| NCT06687772 | RECRUITING | Diffuse Large B Cell Lymphoma |
Washington University School of Medicine |
2025-01-16 | PHASE2 |
| NCT03980769 | RECRUITING | Non-Neoplastic Hematopoietic and Lymphoid Cell Disorder |
Fred Hutchinson Cancer Center |
2021-05-05 | PHASE2 |
| NCT07604987 | RECRUITING | Primary Central Nervous System (CNS) Lymphoma |
Zou Dehui |
2026-05-20 | PHASE2 |
| NCT07588594 | RECRUITING | Chronic Myelomonocytic Leukemia (CMML) |
Peking University People's Hospital |
2026-02-13 | |
| NCT05088356 | ACTIVE_NOT_RECRUITING | Allogeneic Hematopoietic Cell Transplantation (HCT); Advanced Hematologic Malignancies; Acute Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndromes; Myeloproliferative Disorders |
Stanford University |
2021-09-07 | PHASE1 |
| NCT07542418 | NOT_YET_RECRUITING | Multiple Myeloma |
First Affiliated Hospital Xi'an Jiaotong University |
2026-04-20 | |
| NCT06869265 | RECRUITING | Acute Myeloid Leukemia (AML); High Risk Acute Myeloid Leukemia(AML); Relapsed/Refractory Acute Myeloid Leukemia (AML) |
Peking University People's Hospital |
2025-05-01 | PHASE2 |
| NCT07481669 | RECRUITING | Lymphoma Patients With High-risk of Central Nervous System Relapse |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2026-03-01 | PHASE2 |
| NCT07511725 | RECRUITING | Glioblastoma (GBM) |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2026-01-04 | PHASE2 |
| NCT06646211 | NOT_YET_RECRUITING | Primary Central Nervous System Lymphoma (PCNSL); Non Hodgkin Lymphoma (NHL) |
Sun Yat-sen University |
2025-01-01 | PHASE2 |
| NCT03970096 | RECRUITING | Acute Leukemia; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Myelodysplastic Syndrome; Myeloproliferative Neoplasm |
Fred Hutchinson Cancer Center |
2019-11-19 | PHASE2 |
| NCT04708054 | RECRUITING | Acute Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome |
M.D. Anderson Cancer Center |
2021-10-21 | PHASE2; PHASE3 |
| NCT07441967 | NOT_YET_RECRUITING | Hematologic Malignancies |
Institute of Hematology & Blood Diseases Hospital, China |
2026-02-20 | PHASE2 |
| NCT06946407 | RECRUITING | Primary Central Nervous System Lymphoma (PCNSL); CNS Lymphoma Treatment |
FengYan Jin |
2022-12-02 | |
| NCT03500731 | RECRUITING | Idiopathic Pulmonary Fibrosis; Emphysema or COPD |
Paul Szabolcs |
2018-04-19 | PHASE1; PHASE2 |
| NCT06807606 | RECRUITING | Hematologic Malignancies |
M.D. Anderson Cancer Center |
2025-03-03 | PHASE2 |
| NCT06680661 | RECRUITING | Acute Myelogenous Leukemia; Acute Lymphatic Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndromes; Myelodysplastic Syndrome Other; Chronic Myelomonocytic Leukemia; Lymphoma; Hodgkin Lymphoma |
Leland Metheny |
2025-02-25 | PHASE2 |
| NCT07263425 | RECRUITING | Leptomeningeal Metastasis of HER2-positive Breast Cancer |
The First Affiliated Hospital with Nanjing Medical University |
2025-10-27 | PHASE2 |
| NCT06252870 | RECRUITING | Graft Versus Host Disease; Hematologic Malignancy |
Nantes University Hospital |
2024-07-18 | PHASE2 |
| NCT07191431 | RECRUITING | Lymphoma Cns |
Ruijin Hospital |
2025-09-22 | |
| NCT07778940 | NOT_YET_RECRUITING | Leptomeningeal Metastasis |
Tianjin Medical University Cancer Institute and Hospital |
2026-09 | PHASE2 |
| NCT05303727 | NOT_YET_RECRUITING | Neuroblastoma |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
2022-08 | PHASE2 |
| NCT03597594 | ACTIVE_NOT_RECRUITING | Severe Combined Immunodeficiency |
St. Jude Children's Research Hospital |
2021-09-02 | PHASE1; PHASE2 |
| NCT04859946 | ACTIVE_NOT_RECRUITING | Hematologic and Lymphocytic Disorder |
M.D. Anderson Cancer Center |
2022-01-11 | PHASE2 |
| NCT07193654 | RECRUITING | Glioblastoma (GBM) |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2025-04-01 | PHASE2 |
| NCT04872595 | ACTIVE_NOT_RECRUITING | Acute Myeloid Leukemia (AML); Acute Lymphoid Leukemia (ALL); Myelodysplastic Syndromes (MDS) |
Memorial Sloan Kettering Cancer Center |
2021-04-30 | PHASE2 |
| NCT06832267 | RECRUITING | Primary Central Nervous System Lymphoma |
Zhejiang Cancer Hospital |
2025-02-14 | |
| NCT06385808 | NOT_YET_RECRUITING | Relapse Leukemia; Refractory Acute Myeloid Leukemia; Conditioning; Hematopoietic Stem Cell Transplantation |
First Affiliated Hospital Xi'an Jiaotong University |
2024-05-01 | |
| NCT07014943 | RECRUITING | Primary Central Nervous System Lymphoma (PCNSL) |
Sichuan University |
2022-01-01 | PHASE2 |
| NCT06543992 | RECRUITING | Leptomeningeal Metastasis of Breast Cancer |
The First Affiliated Hospital with Nanjing Medical University |
2024-08-08 | PHASE2 |
| NCT01746849 | ACTIVE_NOT_RECRUITING | Leukemia; Multiple Myeloma; Myelodysplastic Syndrome; Non-Hodgkin's Lymphoma |
Memorial Sloan Kettering Cancer Center |
2012-12 | PHASE2 |
| NCT00692939 | RECRUITING | Crohn's Disease |
Paul Szabolcs |
2012-06-26 | PHASE1; PHASE2 |
| NCT04221035 | RECRUITING | High-Risk Neuroblastoma; Patient With Insufficient Response Chemoimmunotherapy |
Gustave Roussy, Cancer Campus, Grand Paris |
2019-11-05 | PHASE3 |
| NCT01962415 | RECRUITING | Primary Immunodeficiency (PID); Congenital Bone Marrow Failure Syndromes; Inherited Metabolic Disorders (IMD); Hereditary Anemias; Inflammatory Conditions; Systemic Juvenile Idiopathic Arthritis (sJIA); Juvenile Rheumatoid Arthritis (JRA) |
Paul Szabolcs |
2014-02-04 | PHASE2 |
| NCT06901999 | NOT_YET_RECRUITING | CNS Lymphoma |
Ruijin Hospital |
2025-04 | PHASE2 |
| NCT02605421 | RECRUITING | Neuroblastoma |
Masonic Cancer Center, University of Minnesota |
2016-06 | PHASE2 |
| NCT06060782 | RECRUITING | Burkitt Lymphoma; Lymphoblastic Lymphoma, Adult; Acute Lymphoblastic Leukemia, Adult |
Fifth Affiliated Hospital, Sun Yat-Sen University |
2024-03-06 | PHASE1 |
| NCT06468267 | UNKNOWN | Peripheral T Cell Lymphoma |
Xianmin Song, MD |
2024-07-15 | PHASE2 |
| NCT02061800 | UNKNOWN | Chronic Myeloid Leukemia (CML); Acute Myelogenous Leukemia (AML); Myelodysplastic Syndrome (MDS); Juvenile Myelomonocytic Leukemia (JMML); Acute Lymphoblastic Leukemia (ALL); Lymphoma (Hodgkin's and Non-Hodgkin's) |
Diane George |
2013-06-03 | PHASE1; PHASE2 |
| NCT05457556 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Mixed Phenotype Acute Leukemia; Myelodysplastic Syndrome |
Children's Oncology Group |
2023-03-15 | PHASE3 |
| NCT04362293 | ACTIVE_NOT_RECRUITING | Sickle Cell Disease |
St. Jude Children's Research Hospital |
2020-04-30 | PHASE2 |
| NCT04217278 | ACTIVE_NOT_RECRUITING | Acute Myeloid Leukaemia; High-risk Myelodysplastic Syndrome |
University of Birmingham |
2020-01-27 | PHASE2; PHASE3 |
| NCT06376292 | COMPLETED | Solid Tumor Leptomeningeal Metastasis |
Second Affiliated Hospital, Zhejiang University, School of Medicine |
2024-01-06 | PHASE2 |
| NCT02790515 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia (ALL); Acute Myeloid Leukemia (AML); Myeloid Sarcoma; Chronic Myeloid Leukemia (CML); Juvenile Myelomonocytic Leukemia (JMML); Myelodysplastic Syndrome (MDS); Non-Hodgkin Lymphoma (NHL) |
St. Jude Children's Research Hospital |
2016-07-14 | PHASE2 |
| NCT03399773 | ACTIVE_NOT_RECRUITING | Acute Biphenotypic Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts |
Fred Hutchinson Cancer Center |
2022-05-10 | PHASE2 |
| NCT01821781 | ACTIVE_NOT_RECRUITING | Immune Deficiency Disorders; Severe Combined Immunodeficiency; Chronic Granulomatous Disease; X-linked Agammaglobulinemia; Wiskott-Aldrich Syndrome; Hyper-IgM; DiGeorge Syndrome; Chediak-Higashi Syndrome; Common Variable Immune Deficiency; Immune Dysregulatory Disorders; Hemophagocytic Lymphohistiocytosis; IPEX; Autoimmune Lymphoproliferative Syndrome; X-linked Lymphoproliferative Syndrome |
Washington University School of Medicine |
2013-04-29 | PHASE2 |
| NCT02220985 | COMPLETED | Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Biphenotypic Leukemia; Acute Leukemia of Ambiguous Lineage; Acute Undifferentiated Leukemia; Allogeneic Hematopoietic Stem Cell Transplant Recipient; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Blastic Plasmacytoid Dendritic Cell Neoplasm; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Donor; Lymphoblastic Lymphoma; Myelodysplastic Syndrome With Excess Blasts; Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome With Excess Blasts-2; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission |
Fred Hutchinson Cancer Center |
2015-03-23 | PHASE2 |
| NCT03263559 | COMPLETED | Sickle Cell Disease |
Medical College of Wisconsin |
2017-10-03 | PHASE2 |
| NCT05931328 | RECRUITING | Relapsed or Refractory (R/R) Primary Central Nervous System Lymphoma |
The First Affiliated Hospital with Nanjing Medical University |
2022-10-15 | PHASE2 |
| NCT06625359 | TERMINATED | Central Nervous System Lymphoma |
Seoul National University Hospital |
2015-06-01 | PHASE2 |
| NCT05598593 | UNKNOWN | Cytarabine+Thiotepa + Fludarabine + Busulfan; T Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma |
First Affiliated Hospital of Zhejiang University |
2022-10-23 | PHASE2 |
| NCT04530487 | TERMINATED | Desmoplastic Small Round Cell Tumor; Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Desmoplastic Small Round Cell Tumor; Recurrent Malignant Peripheral Nerve Sheath Tumor; Recurrent Malignant Solid Neoplasm; Recurrent Neuroblastoma; Recurrent Rhabdomyosarcoma; Refractory Desmoplastic Small Round Cell Tumor; Refractory Malignant Peripheral Nerve Sheath Tumor; Refractory Malignant Solid Neoplasm; Refractory Neuroblastoma; Refractory Rhabdomyosarcoma |
M.D. Anderson Cancer Center |
2020-08-19 | PHASE2 |
| NCT03849651 | ACTIVE_NOT_RECRUITING | Acute Lymphoblastic Leukemia (ALL); Acute Myeloid Leukemia (AML); Myelodysplastic Syndromes (MDS); NK-Cell Leukemia; Hodgkin Lymphoma; Non Hodgkin Lymphoma (NHL); Juvenile Myelomonocytic Leukemia (JMML); Chronic Myeloid Leukemia (CML) |
St. Jude Children's Research Hospital |
2019-01-31 | PHASE2 |
| NCT03346096 | COMPLETED | Malignant Lymphoma |
Sheba Medical Center |
2018-10-09 | PHASE2 |
| NCT03342196 | COMPLETED | Leukemia |
Case Comprehensive Cancer Center |
2018-03-21 | PHASE2 |
| NCT05854225 | UNKNOWN | HLH |
Beijing Friendship Hospital |
2022-01-01 | |
| NCT05579769 | TERMINATED | Hematologic Malignancy; Myeloid Malignancy |
St. Jude Children's Research Hospital |
2023-03-14 | PHASE2 |
| NCT03615105 | TERMINATED | Acute Lymphoid Leukemia (ALL); Acute Myeloid Leukemia (AML); Chronic Myeloid Leukemia (CML); Hodgkin Lymphoma; Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia |
Memorial Sloan Kettering Cancer Center |
2018-07-25 | PHASE2 |
| NCT01505569 | COMPLETED | Ewing's Family Tumors; Renal Tumors; Hepatoblastoma; Rhabdomyosarcoma; Soft Tissue Sarcoma; Primary Malignant Brain Neoplasms; Retinoblastoma; Medulloblastoma; Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET); Atypical Teratoid/Rhabdoid Tumor (AT/RT); CNS Tumors; Germ Cell Tumors |
Masonic Cancer Center, University of Minnesota |
2011-10-20 | |
| NCT00719888 | COMPLETED | Acute Biphenotypic Leukemia; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Burkitt Lymphoma; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Follicular Lymphoma; Lymphoblastic Lymphoma; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Myelodysplastic Syndrome; Myelofibrosis; Non-Hodgkin Lymphoma; Plasma Cell Myeloma; Prolymphocytic Leukemia; Refractory Anemia; Small Lymphocytic Lymphoma |
Fred Hutchinson Cancer Center |
2005-11-18 | PHASE2 |
| NCT02880293 | COMPLETED | Hematologic Malignancy |
Memorial Sloan Kettering Cancer Center |
2016-08-23 | |
| NCT04151706 | COMPLETED | Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndromes; Acute Leukemia; Chronic Myeloid Leukemia |
Robert Lowsky |
2020-02-27 | PHASE2 |
| NCT07493486 | COMPLETED | Diffuse Large B-Cell Lymphoma (DLBCL); Intrathecal Chemotherapy |
Zhejiang Cancer Hospital |
2022-02-01 | PHASE2 |
| NCT03165292 | TERMINATED | Very High Risk Neuroblastoma |
Gustave Roussy, Cancer Campus, Grand Paris |
2018-10-01 | PHASE2 |
| NCT01057069 | ACTIVE_NOT_RECRUITING | Breast Cancer |
The Netherlands Cancer Institute |
2010-01 | PHASE2; PHASE3 |
| NCT00588523 | COMPLETED | CNS Cancer; CNS BRAIN |
Memorial Sloan Kettering Cancer Center |
2002-09 | PHASE2 |
| NCT00596154 | COMPLETED | CNS Lymphoma; CNS Brain Cancer; Non-Hodgkin's Lymphoma |
Memorial Sloan Kettering Cancer Center |
2004-12 | PHASE2 |
| NCT01858740 | COMPLETED | Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Biphenotypic Leukemia; Acute Leukemia of Ambiguous Lineage; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Myelodysplastic Syndrome With Excess Blasts-1; Myelodysplastic Syndrome With Excess Blasts-2; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Refractory Adult Acute Lymphoblastic Leukemia; Refractory Childhood Acute Lymphoblastic Leukemia |
Fred Hutchinson Cancer Center |
2014-04-10 | PHASE2 |
| NCT01646034 | ACTIVE_NOT_RECRUITING | Breast Cancer |
The Netherlands Cancer Institute |
2014-09 | PHASE3 |
| NCT00790413 | UNKNOWN | Neuroblastoma |
Lund University Hospital |
2005-08 | EARLY_PHASE1 |
| NCT04521946 | WITHDRAWN | Anaplastic Ependymoma; Atypical Teratoid/Rhabdoid Tumor; Central Nervous System Germ Cell Tumor; Choroid Plexus Carcinoma; Intracranial Myeloid Sarcoma; Malignant Brain Neoplasm; Malignant Glioma; Medulloblastoma; Primitive Neuroectodermal Tumor; Recurrent Anaplastic Ependymoma; Recurrent Atypical Teratoid/Rhabdoid Tumor; Recurrent Malignant Brain Neoplasm; Recurrent Malignant Glioma; Recurrent Medulloblastoma; Recurrent Primitive Neuroectodermal Tumor |
M.D. Anderson Cancer Center |
2021-01-14 | PHASE1 |
| NCT05021770 | UNKNOWN | Refractory and Relapsed Primary CNS Lymphoma; PCNSL; Non Hodgkin Lymphoma |
Huiqiang Huang |
2021-12 | PHASE1; PHASE2 |
| NCT04083170 | TERMINATED | Acute Erythroid Leukemia; Acute Lymphoblastic Leukemia; Acute Megakaryoblastic Leukemia; Acute Myeloid Leukemia; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; HIV Infection; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts; Non-Hodgkin Lymphoma; Refractory Anemia |
Fred Hutchinson Cancer Center |
2022-10-06 | PHASE2 |
| NCT03513328 | COMPLETED | Bone Marrow Failure Syndrome; Thalassemia; Sickle Cell Disease; Diamond Blackfan Anemia; Acquired Neutropenia in Newborn; Acquired Anemia Hemolytic; Acquired Thrombocytopenia; Hemophagocytic Lymphohistiocytoses; Wiskott-Aldrich Syndrome; Chronic Granulomatous Disease; Common Variable Immunodeficiency; X-linked Lymphoproliferative Disease; Severe Combined Immunodeficiency; Hurler Syndrome; Mannosidosis; Adrenoleukodystrophy |
University of Florida |
2018-06-15 | PHASE1; PHASE2 |
| NCT03786783 | COMPLETED | Ganglioneuroblastoma; High Risk Neuroblastoma |
National Cancer Institute (NCI) |
2019-03-04 | PHASE2 |
| NCT02867800 | COMPLETED | Sickle Cell Disease; Graft Versus Host Disease |
Monica Bhatia |
2016-07 | PHASE1 |
| NCT02757885 | COMPLETED | Sickle Cell Disease |
Emory University |
2019-07-10 | PHASE2 |
| NCT05021770 | Not yet recruiting | Refractory and Relapsed Primary CNS Lymphoma|PCNSL|Non Hodgkin Lymphoma |
Huiqiang Huang|Guangdong 999 Brain Hospital|Sun Yat-sen University |
2021-12 | Phase 1|Phase 2 |
| NCT00739141 | COMPLETED | Leukemia; Myelodysplastic Syndrome; Non-Hodgkins Lymphoma; Chronic Myelogenous Leukemia; Hodgkins Lymphoma |
Memorial Sloan Kettering Cancer Center |
2008-08-12 | PHASE2 |
| NCT01807611 | COMPLETED | Leukemia; Lymphoma |
St. Jude Children's Research Hospital |
2013-05-16 | PHASE2 |
| NCT00423514 | COMPLETED | Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes |
Memorial Sloan Kettering Cancer Center |
2006-11-20 | PHASE1; PHASE2 |
| NCT01119066 | COMPLETED | Acute Lymphoblastic Leukemia; Acute Myelogenous Leukemia; Myelodysplastic Syndrome; Multiple Myeloma |
Memorial Sloan Kettering Cancer Center |
2010-05-03 | PHASE2 |
| NCT03885947 | COMPLETED | Hematological Malignancy; Acute Leukemia in Remission; Acute Lymphoblastic Leukemia in Remission; Myelodysplastic Syndromes; Non-Hodgkin Lymphoma; Hodgkin Lymphoma |
Alla Keyzner |
2019-02-21 | PHASE1 |
| NCT02784054 | UNKNOWN | Intracranial Non-germinomatous Germ Cell Tumor |
Samsung Medical Center |
2014-04 | PHASE2 |
| NCT00432094 | COMPLETED | Childhood Germ Cell Tumor; Ovarian Cancer; Teratoma |
Masonic Cancer Center, University of Minnesota |
2006-12-19 | PHASE2 |
| NCT01511562 | ACTIVE_NOT_RECRUITING | Lymphoma |
Alliance for Clinical Trials in Oncology |
2012-09 | PHASE2 |
| NCT02707393 | COMPLETED | Chronic Myeloid Leukemia |
St. Anna Kinderkrebsforschung |
2009-04-30 | PHASE2; PHASE3 |
| NCT03615144 | TERMINATED | Non-Malignant Hematologic Disorders |
Memorial Sloan Kettering Cancer Center |
2018-07-23 | PHASE2 |
| NCT02025881 | TERMINATED | High-risk Medulloblastoma |
Gustave Roussy, Cancer Campus, Grand Paris |
2013-09-14 | PHASE1; PHASE2 |
| NCT02784015 | UNKNOWN | Unresectable Localized Soft Tissue Sarcoma |
Samsung Medical Center |
2016-05 | PHASE2 |
| NCT00867178 | COMPLETED | Medulloblastoma; Pineoblastoma; Supratentorial Embryonal Tumor, Not Otherwise Specified |
National Cancer Institute (NCI) |
2009-02-25 | PHASE1 |
| NCT00914940 | TERMINATED | Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes |
Fred Hutchinson Cancer Center |
2009-12-17 | PHASE2 |
| NCT02724904 | WITHDRAWN | Lymphoma |
Massachusetts General Hospital |
2017-05 | PHASE1; PHASE2 |
| NCT02660281 | COMPLETED | Hematological Disease; Immune Deficiencies; Solid Tumors; Myelofibrosis; Multiple Myeloma; Lymphoma |
University of Rochester |
2015-10 | PHASE1 |
| NCT03434704 | COMPLETED | Transplant-Related Hematologic Malignancy; Leukemia, Acute; Myelodysplastic Syndromes; Graft Vs Host Disease; Fungal Infection |
Ciceri Fabio |
2018-06-18 | PHASE2 |
| NCT02329080 | COMPLETED | Diffuse Large B-cell Lymphoma |
International Extranodal Lymphoma Study Group (IELSG) |
2014-12 | PHASE2 |
| NCT00003816 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Nonmalignant Neoplasm; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
Roswell Park Cancer Institute |
1998-10-19 | PHASE2; PHASE3 |
| NCT00857389 | COMPLETED | Stem Cell Transplantation; Leukemia; Lymphoma |
M.D. Anderson Cancer Center |
2009-03-02 | PHASE2 |
| NCT00978471 | COMPLETED | Osteosarcoma |
Centre Leon Berard |
2009-07 | PHASE2 |
| NCT01690520 | COMPLETED | Acute Biphenotypic Leukemia; Acute Lymphoblastic Leukemia in Remission; Acute Myeloid Leukemia in Remission; Chronic Myelogenous Leukemia; Myelodysplastic Syndrome |
Nohla Therapeutics, Inc. |
2012-12-11 | PHASE2 |
| NCT00943800 | COMPLETED | Leukemia; Myelodysplastic Syndrome; Multiple Myeloma; Lymphoma |
University of Chicago |
2006-10-09 | |
| NCT00536601 | COMPLETED | Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Acute Myeloid Leukemia in Remission; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (PNET); Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Plasma Cell Neoplasm; Primary Systemic Amyloidosis; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Neuroblastoma; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Regional Neuroblastoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia |
Roswell Park Cancer Institute |
2006-06-29 | |
| NCT00554788 | COMPLETED | Extraocular Retinoblastoma |
Children's Oncology Group |
2008-05-06 | PHASE3 |
| NCT02333838 | UNKNOWN | Leukemia, Myeloid |
Assistance Publique - Hôpitaux de Paris |
2015-05 | PHASE2 |
| NCT01598025 | TERMINATED | Acute Leukemia; Chronic Leukemia; Myelodysplastic Syndrome; Non-Hodgkins Lymphoma |
Memorial Sloan Kettering Cancer Center |
2012-05-02 | |
| NCT01010217 | COMPLETED | Blood Stem Cell Transplant Failure; Leukemia; Hematologic Malignancies |
M.D. Anderson Cancer Center |
2009-11-05 | PHASE2 |
| NCT02653196 | TERMINATED | Neuroepithelial Tumor; Solid Tumor; Allogeneic Hematopoietic Stem Cell Transplantation |
Montefiore Medical Center |
2015-09 | EARLY_PHASE1 |
| NCT02507479 | UNKNOWN | Non Hodgkin Lymphoma; Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Multiple Myeloma |
Sheba Medical Center |
2015-09 | PHASE2 |
| NCT00528437 | COMPLETED | Brain Tumors |
NYU Langone Health |
2005-10 | PHASE2 |
| NCT02199041 | TERMINATED | Hematological Malignancies |
St. Jude Children's Research Hospital |
2014-07-11 | PHASE2 |
| NCT03609840 | Completed | Hematologic Malignancies|Nonmalignant Diseases|Immune Deficiency|Hemoglobinopathies|Genetic Inborn Errors of Metabolism|Fanconi Anemia|Thalassemia|Sickle Cell Disease |
University of California San Francisco |
2017-05-24 | -- |
| NCT00336024 | COMPLETED | Anaplastic Medulloblastoma; Medulloblastoma; Supratentorial Embryonal Tumor, Not Otherwise Specified; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor |
Children's Oncology Group |
2007-10-22 | PHASE3 |
| NCT01814475 | COMPLETED | Myelofibrosis |
Gruppo Italiano Trapianto di Midollo Osseo |
2011-07 | PHASE2 |
| NCT00653068 | COMPLETED | Childhood Atypical Teratoid/Rhabdoid Tumor |
Children's Oncology Group |
2009-02-10 | PHASE3 |
| NCT00593554 | TERMINATED | Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Myelodysplasia; Chronic Myeloid Leukemia |
Sherif S. Farag |
2007-08-07 | PHASE2 |
| NCT02049580 | UNKNOWN | Lymphoma |
Istituto Clinico Humanitas |
2013-07 | PHASE2 |
| NCT00067002 | COMPLETED | Leukemia, Lymphocytic, Acute; Leukemia, Myelocytic, Acute; Leukemia, Myeloid, Chronic; Lymphoma, Non-Hodgkin |
M.D. Anderson Cancer Center |
2003-04 | PHASE2 |
| NCT00961142 | TERMINATED | Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia |
University Hospital Tuebingen |
2009-06 | PHASE2 |
| NCT01182415 | COMPLETED | Non-Hodgkin's Lymphoma; CNS Lymphoma |
Massachusetts General Hospital |
2010-06 | PHASE2 |
| NCT01810926 | UNKNOWN | Graft Versus Host Disease |
Franco Locatelli |
2011-09 | PHASE2 |
| NCT00238433 | COMPLETED | Lymphoma |
OHSU Knight Cancer Institute |
2005-03 | PHASE2 |
| NCT02259348 | TERMINATED | Acute Lymphoblastic Leukemia (ALL); Acute Myeloid Leukemia (AML); Myeloid Sarcoma; Chronic Myelogenous Leukemia (CML); Juvenile Myelomonocytic Leukemia (JMML); Myelodysplastic Syndrome (MDS); Non-Hodgkin Lymphoma (NHL) |
St. Jude Children's Research Hospital |
2014-10 | PHASE2 |
| NCT01011920 | COMPLETED | Central Nervous System Lymphoma |
International Extranodal Lymphoma Study Group (IELSG) |
2009-11 | PHASE2 |
| NCT00567567 | COMPLETED | Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2007-11-05 | PHASE3 |
| NCT01786018 | UNKNOWN | B-cell Lymphoma Refractory |
Azienda Ospedaliera San Giovanni Battista |
2013-02 | PHASE2 |
| NCT00749723 | COMPLETED | Recurrent Brain Tumors; Supratentorial PNETs; Medulloblastomas; Ependymomas |
University Hospital, Bonn |
2006-02-01 | PHASE2; PHASE3 |
| NCT00793845 | COMPLETED | Neuroblastoma |
Samsung Medical Center |
2008-08 | PHASE2 |
| NCT00182793 | COMPLETED | Breast Cancer |
City of Hope Medical Center |
2005-07 | PHASE2 |
| NCT00317408 | UNKNOWN | Lymphoma |
European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma |
2004-04 | |
| NCT03061656 | UNKNOWN | High Risk Neuroblastoma |
Samsung Medical Center |
2009-01-01 | PHASE2 |
| NCT00004092 | COMPLETED | Breast Cancer |
City of Hope Medical Center |
1999-05 | PHASE2 |
| NCT00303810 | COMPLETED | Brain and Central Nervous System Tumors |
Universitätsklinikum Hamburg-Eppendorf |
2001-01 | |
| NCT00462787 | COMPLETED | Leukemia |
Memorial Sloan Kettering Cancer Center |
2007-04 | PHASE1 |
| NCT00647049 | UNKNOWN | Primary Non Hodgkin Lymphoma of the Central Nervous System |
University Hospital Freiburg |
2007-01 | PHASE2 |
| NCT00020722 | TERMINATED | Breast Cancer |
Barbara Ann Karmanos Cancer Institute |
2007-08 | PHASE2 |
| NCT01025778 | COMPLETED | Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia |
Lund University Hospital |
2009-12 | PHASE2 |
| NCT00824135 | COMPLETED | Hematologic Malignancies |
St. Jude Children's Research Hospital |
2009-01 | PHASE1 |
| NCT01050764 | TERMINATED | Leukemia, Acute; Chronic Myelogenous Leukemia (CML); Myelodysplastic Syndrome (MDS); Non-Hodgkin Lymphoma (NHL); Chronic Lymphocytic Leukemia (CLL); Acute Myelogenous Leukemia (AML); Acute Lymphoblastic Leukemia (ALL) |
Everett Meyer |
2009-06 | PHASE1; PHASE2 |
| NCT00623077 | TERMINATED | Brain and Central Nervous System Tumors; Kidney Cancer; Liver Cancer; Retinoblastoma; Sarcoma |
Masonic Cancer Center, University of Minnesota |
2005-08 | PHASE1 |
| NCT01350258 | TERMINATED | Hematologic Malignancies; Acute Leukemia; Myelodysplastic Syndromes (MDS) Other Than RA or RARS Subtypes; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; Myeloma; Chronic Myelogenous (or Myeloid) Leukemia (CML) Resistant to STI Therapy |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2011-04 | PHASE1; PHASE2 |
| NCT00916045 | TERMINATED | Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Leukemia, Lymphoblastic, Acute; Lymphoma, Non-Hodgkin; Hodgkin Disease; Chronic Lymphocytic Leukemia |
King's College Hospital NHS Trust |
2009-09 | PHASE2 |
| NCT00429182 | COMPLETED | Breast Cancer; Metastatic Breast Carcinoma; Invasive Breast Carcinoma |
M.D. Anderson Cancer Center |
2007-06 | PHASE2 |
| NCT00936156 | COMPLETED | Metastatic, Cerebral Primitive Neuroectodermal Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
2009-01 | PHASE2 |
| NCT00295971 | COMPLETED | Congenital Amegakaryocytic Thrombocytopenia; Leukemia; Myelodysplastic Syndromes; Severe Congenital Neutropenia |
University of California, San Francisco |
2005-04 | PHASE1 |
| NCT00972101 | WITHDRAWN | Stem Cell Transplantation; Leukemia; Lymphoma; Pediatric Disorders |
M.D. Anderson Cancer Center |
2009-09 | PHASE1 |
| NCT01423747 | UNKNOWN | Lymphoblastic Leukemia, Acute, Childhood; |
St. Anna Kinderkrebsforschung |
2003-07 | PHASE3 |
| NCT01423500 | UNKNOWN | Lymphoblastic Leukemia, Acute, Childhood; |
St. Anna Kinderkrebsforschung |
2007-01 | PHASE3 |
| NCT00382109 | COMPLETED | B-cell Childhood Acute Lymphoblastic Leukemia; Childhood Acute Lymphoblastic Leukemia in Remission; Graft Versus Host Disease; L1 Childhood Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia |
Children's Oncology Group |
2007-03 | PHASE3 |
| NCT00392782 | TERMINATED | Leukemia; Myelodysplastic Syndromes |
Masonic Cancer Center, University of Minnesota |
2005-07 | PHASE2 |
| NCT00587054 | COMPLETED | Allogeneic Stem Cell Transplant; Leukemia; Non-Hodgkins; Lymphoblastic Lymphoma; Myelodysplastic Syndrome; Paroxysmal Nocturnal Hemoglobinuria (PNH) |
Memorial Sloan Kettering Cancer Center |
2001-06 | PHASE2 |
| NCT00644371 | COMPLETED | Non-Hodgkin Lymphoma |
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea |
2007-11 | PHASE2 |
| NCT05167370 | Terminated | Solid Tumors|Brain Tumors |
Children''s Hospital Medical Center Cincinnati |
2010-12-13 | Phase 2 |
| NCT00392886 | UNKNOWN | Brain and Central Nervous System Tumors |
Children's Hospital Los Angeles |
2004-03 | PHASE3 |
| NCT00607984 | UNKNOWN | Central Nervous System Tumors; Tumors |
Rabin Medical Center |
2006-06 | |
| NCT00450983 | TERMINATED | Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes |
Fred Hutchinson Cancer Center |
2006-12 | PHASE2 |
| NCT00376480 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Dana-Farber Cancer Institute |
2005-06 | PHASE1 |
| NCT01068301 | Completed | Acute Lymphoblastic Leukemia|Acute Myeloid Leukemia|Chronic Myeloid Leukemia|Myelodysplastic Syndrome|Non-Hodgkin''s Lymphoma |
St. Jude Children''s Research Hospital|Genzyme a Sanofi Company |
2010-05 | Phase 1 |
| NCT00448266 | TERMINATED | Breast Cancer |
The Netherlands Cancer Institute |
2007-05 | PHASE2; PHASE3 |
| NCT00003199 | COMPLETED | Estrogen Receptor-negative Breast Cancer; Estrogen Receptor-positive Breast Cancer; Inflammatory Breast Cancer; Male Breast Cancer; Progesterone Receptor-negative Breast Cancer; Progesterone Receptor-positive Breast Cancer; Stage IIIB Breast Cancer; Stage IV Breast Cancer |
Fred Hutchinson Cancer Center |
1997-11 | PHASE2 |
| NCT00357396 | COMPLETED | Sarcoma |
Memorial Sloan Kettering Cancer Center |
2005-06 | PHASE2 |
| NCT00202917 | COMPLETED | Hematologic Malignancies |
University Hospital Tuebingen |
2004-02 | PHASE1; PHASE2 |
| NCT00038857 | COMPLETED | Leukemia; Lymphoma |
M.D. Anderson Cancer Center |
2001-09 | PHASE2 |
| NCT00801931 | TERMINATED | Leukemia; Lymphoma; Neuroblastoma; Immunodeficiencies; Anemia |
Columbia University |
2007-09-06 | PHASE1; PHASE2 |
| NCT00047320 | COMPLETED | Brain Tumor; Central Nervous System Tumors; Childhood Germ Cell Tumor |
Children's Oncology Group |
2004-01 | PHASE2 |
| NCT00621036 | WITHDRAWN | Brain and Central Nervous System Tumors; Lymphoma; Lymphoproliferative Disorder; Small Intestine Cancer |
University of Texas Southwestern Medical Center |
2007-10-19 | PHASE2 |
| NCT00160355 | COMPLETED | Wiskott-Aldrich Syndrome |
St. Jude Children's Research Hospital |
2005-05 | PHASE1 |
| NCT00004174 | COMPLETED | Breast Cancer |
Northwestern University |
1999-10 | PHASE1 |
| NCT00104975 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms |
Yale University |
2005-02 | PHASE1 |
| NCT00003141 | COMPLETED | Brain Tumors; Central Nervous System Tumors; Neuroblastoma; Sarcoma |
Children's Oncology Group |
1998-03 | PHASE1 |
| NCT00025558 | COMPLETED | Brain and Central Nervous System Tumors |
NYU Langone Health |
2000-10 | PHASE1 |
| NCT00040872 | COMPLETED | Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2000-06 | PHASE2 |
| NCT00078988 | COMPLETED | Brain Tumor; Central Nervous System Tumor |
Children's Oncology Group |
2004-10 | PHASE3 |
| NCT00060255 | COMPLETED | Breast Cancer; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Testicular Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
Roswell Park Cancer Institute |
1991-12 | PHASE2 |
| NCT00028730 | COMPLETED | Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms |
Memorial Sloan Kettering Cancer Center |
2001-08 | PHASE2 |
| NCT00002836 | COMPLETED | Breast Cancer |
M.D. Anderson Cancer Center |
1995-09-26 | PHASE3 |
| NCT00008203 | COMPLETED | Breast Cancer |
Herbert Irving Comprehensive Cancer Center |
1996-05 | PHASE3 |
| NCT00017368 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2001-04 | PHASE2 |
| NCT00008008 | COMPLETED | Brain and Central Nervous System Tumors |
Herbert Irving Comprehensive Cancer Center |
1997-09 | PHASE2 |
| NCT00002515 | COMPLETED | Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Head and Neck Cancer; Kidney Cancer; Liver Cancer; Lymphoma; Neuroblastoma; Ovarian Cancer; Retinoblastoma; Sarcoma; Testicular Germ Cell Tumor |
Memorial Sloan Kettering Cancer Center |
1992-10 | PHASE2 |
| NCT00007982 | COMPLETED | Brain and Central Nervous System Tumors; Head and Neck Cancer; Lymphoma |
Herbert Irving Comprehensive Cancer Center |
1999-04 | PHASE2 |
| NCT00003846 | COMPLETED | Brain and Central Nervous System Tumors; Neuroblastoma |
Children's Oncology Group |
1999-07 | PHASE2 |
| NCT00002704 | COMPLETED | Leukemia |
National Cancer Institute (NCI) |
1996-01 | PHASE2 |
| NCT00002772 | TERMINATED | Breast Cancer |
SWOG Cancer Research Network |
1996-07 | PHASE3 |
| NCT00002718 | COMPLETED | Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms |
Memorial Sloan Kettering Cancer Center |
1995-11 | PHASE2 |
| NCT00004172 | COMPLETED | Breast Cancer |
Northwestern University |
1999-10 | PHASE2 |
| NCT00003173 | COMPLETED | Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer; Retinoblastoma; Testicular Germ Cell Tumor; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
1997-09 | PHASE2 |
| NCT00002534 | COMPLETED | Leukemia |
Memorial Sloan Kettering Cancer Center |
1993-05 | PHASE3 |
| NCT00003972 | COMPLETED | Breast Cancer |
Fred Hutchinson Cancer Center |
1998-07 | PHASE3 |
| NCT00002471 | COMPLETED | Leukemia; Lymphoma |
Memorial Sloan Kettering Cancer Center |
1990-02 | PHASE2 |
| NCT00003194 | TERMINATED | Unspecified Childhood Solid Tumor, Protocol Specific |
Seattle Children's Hospital |
1997-07 | PHASE1 |
| NCT00005092 | COMPLETED | Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes |
M.D. Anderson Cancer Center |
1999-05-28 | PHASE1 |
| NCT00003926 | TERMINATED | Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Chordoma; Kidney Cancer; Liver Cancer; Neuroblastoma; Ovarian Cancer; Retinoblastoma; Sarcoma |
Masonic Cancer Center, University of Minnesota |
1998-11 | PHASE1 |
| NCT00003101 | COMPLETED | Brain and Central Nervous System Tumors |
Memorial Sloan Kettering Cancer Center |
1997-08 | PHASE2 |
| NCT00002870 | COMPLETED | Breast Cancer |
UNICANCER |
1994-12 | PHASE3 |
| NCT00003081 | COMPLETED | Sarcoma |
Fred Hutchinson Cancer Center |
1998-03 | PHASE1 |
| NCT00002977 | COMPLETED | Ovarian Cancer |
Fred Hutchinson Cancer Center |
1997-01 | PHASE1 |
| NCT00002508 | COMPLETED | Extragonadal Germ Cell Tumor; Ovarian Cancer; Testicular Germ Cell Tumor |
Temple University |
1990-11 | PHASE1; PHASE2 |
| NCT00005798 | COMPLETED | Breast Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
1995-07 | PHASE2 |
| NCT00003146 | COMPLETED | Multiple Myeloma and Plasma Cell Neoplasm |
Fred Hutchinson Cancer Center |
1997-11 | PHASE2 |
| NCT00003080 | COMPLETED | Ovarian Cancer |
Fred Hutchinson Cancer Center |
1996-09 | PHASE1 |
| NCT00003086 | TERMINATED | Breast Cancer |
Louisiana State University Health Sciences Center Shreveport |
1997-03 | PHASE1; PHASE2 |
| NCT00003297 | COMPLETED | Ovarian Cancer |
Georgetown University |
1997-12 | PHASE1; PHASE2 |
| NCT00002680 | COMPLETED | Breast Cancer |
Yale University |
1994-02 | PHASE2 |
| NCT00006123 | WITHDRAWN | Breast Cancer |
Beth Israel Deaconess Medical Center |
2000-07 | PHASE1; PHASE2 |
| NCT00003398 | COMPLETED | Anemia; Graft Versus Host Disease; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes |
University of Maryland, Baltimore |
1998-09 | PHASE4 |
| NCT00002619 | COMPLETED | Brain and Central Nervous System Tumors |
NYU Langone Health |
1994-09 | PHASE2 |
| NCT00003852 | TERMINATED | Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer; Testicular Germ Cell Tumor |
UNICANCER |
1998-03 | PHASE2 |
| NCT00003877 | COMPLETED | Breast Cancer |
Roswell Park Cancer Institute |
1998-09 | PHASE1; PHASE2 |
| NCT00002942 | COMPLETED | Breast Cancer |
Wake Forest University Health Sciences |
1996-06 | PHASE3 |
| NCT00313521 | UNKNOWN | Brain and Central Nervous System Tumors |
Children's Cancer and Leukaemia Group |
1995-06 | PHASE2 |
| NCT00066417 | TERMINATED | Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic/Myeloproliferative Diseases |
National Heart, Lung, and Blood Institute (NHLBI) |
PHASE2 | |
| NCT00112567 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Fred Hutchinson Cancer Center |
2003-04 | PHASE1; PHASE2 |
| NCT00002755 | COMPLETED | Breast Cancer |
Scottish Cancer Therapy Network |
1995-11 | PHASE3 |
| NCT00003068 | COMPLETED | Breast Cancer; Drug/Agent Toxicity by Tissue/Organ |
University of Arizona |
1997-06 | PHASE2 |
| NCT00101140 | WITHDRAWN | Adult Acute Erythroid Leukemia; Adult Acute Monoblastic and Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia |
Eastern Cooperative Oncology Group |
PHASE2 | |
| NCT00003680 | UNKNOWN | Breast Cancer |
Scottish Cancer Therapy Network |
1998-11 | PHASE3 |
| NCT00002616 | UNKNOWN | Breast Cancer |
University of Illinois at Chicago |
1995-02 | PHASE1 |
| NCT00003899 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Fred Hutchinson Cancer Center |
1999-01 | PHASE1 |
| NCT00004906 | COMPLETED | Breast Cancer |
Hackensack Meridian Health |
1999-10 | PHASE2 |
| NCT00003412 | UNKNOWN | Breast Cancer |
Beth Israel Deaconess Medical Center |
1998-06 | PHASE1 |
| NCT00045539 | COMPLETED | Lymphoma |
New Approaches to Brain Tumor Therapy Consortium |
2002-10 | PHASE2 |
| NCT00025077 | COMPLETED | Brain and Central Nervous System Tumors |
Children's Cancer and Leukaemia Group |
2000-01 | PHASE2 |
| NCT00025324 | UNKNOWN | Brain and Central Nervous System Tumors |
Children's Hospital Los Angeles |
2000-12 | PHASE2 |
| NCT00004900 | COMPLETED | Breast Cancer |
Hackensack Meridian Health |
1999-10 | PHASE2 |
| NCT00027937 | COMPLETED | Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
Fred Hutchinson Cancer Center |
2001-08 | PHASE2 |
| NCT00003064 | UNKNOWN | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Herbert Irving Comprehensive Cancer Center |
1997-01 | PHASE1; PHASE2 |
| NCT00002780 | UNKNOWN | Breast Cancer |
St. Luke's Medical Center |
1996-05 | PHASE1; PHASE2 |
| NCT00180791 | UNKNOWN | Medulloblastoma; Brain Tumors; Neuroectodermal Tumors, Primitive |
Gustave Roussy, Cancer Campus, Grand Paris |
2002-07 | PHASE2 |
| NCT00012311 | UNKNOWN | Breast Cancer |
Herbert Irving Comprehensive Cancer Center |
2000-01 | PHASE2 |
| NCT00003273 | WITHDRAWN | Brain and Central Nervous System Tumors; Neuroblastoma; Retinoblastoma; Sarcoma |
NYU Langone Health |
1997-11 | PHASE2 |
(data from https://clinicaltrials.gov, updated on 2026-07-23)
Check the
Thiotepa
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.