CAS No. 85622-93-1
Batch:
Purity:99.99
Chemical Structure
Check the
TMZ(Temozolomide)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | |
|---|---|---|
| CAS Number | 85622-93-1 | |
| Molecular Formula |
C6H6N6O2 |
|
| Molecular Weight (MW) | 194.15 | |
| SMILES | CN1C(=O)N2C=NC(=C2N=N1)C(=O)N | |
| InChIKey | BPEGJWRSRHCHSN-UHFFFAOYSA-N |
Biological Activity
Temozolomide (TMZ) is a monofunctional SN-1 DNA alkylating agent that spontaneously converts at physiological pH to the active metabolite MTIC and methyldiazonium ions, which transfer methyl groups to DNA. This alkylation triggers DNA damage, inducing cell cycle arrest and apoptosis in leukemia and glioma models. Concurrently, temozolomide demonstrates schedule-dependent antitumor activity against various malignancies including high-grade gliomas and metastatic melanoma. [1]
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
39 mg/mL
(200.87 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 10 mg/mL (超声加热五分钟) |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(103.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
39 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
39 mg/mL
(200.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 5 mg/mL |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(103.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 2.5 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- TMZ(Temozolomide) Mechanism of Action: MGMT Inhibition in Glioblastoma Cells Research
- TMZ(Temozolomide) Clinical Trials
- TMZ(Temozolomide) Solubility in DMSO
- TMZ(Temozolomide) Storage
- TMZ(Temozolomide) Stability
- TMZ(Temozolomide) Molecular Weight
- TMZ(Temozolomide) SMILES
- TMZ(Temozolomide) Chemical Structure (2D and 3D)
- TMZ(Temozolomide) Sigma (t2577)? Try a better option.
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- TMZ(Temozolomide) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.