Tauroursodeoxycholic Acid (TUDCA): Mechanism of Action

Tauroursodeoxycholic Acid (TUDCA) MOA:Targeting Endoplasmic Reticulum Stress/Unfolded Protein Response Pathway for Neurodegenerative Diseases

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Tauroursodeoxycholic Acid (TUDCA) is a potent, neuroprotective endoplasmic reticulum (ER) stress inhibitor. It affects UPR, NF-κB, and Nrf-2 signaling pathways by acting as a chemical chaperone to alleviate ER stress and reduce ROS generation, effectively inhibiting apoptosis, inflammation, and oxidative stress.

Primary Applications and Mechanism of Action