For research use only. Not for use in humans.

Tarextumab (Anti-NOTCH3)

Synonyms: OMP 59R5, Anti-Human NOTCH2 Recombinant Antibody, Anti-Human NOTCH 2 Recombinant Antibody Cat.No.A2389 Purity:99%

Tarextumab (Anti-NOTCH3) is an anti-Notch2/3 fully human IgG2 monoclonal antibody with anti-tumor activity. MW: 145.5 kD.

Quality Control

Batch: Purity: 99% Protein concentration: 7.22mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	Notch	Others
RO4929097 (RG-4733)	124	+++	γ secretase,Aβ40
Semagacestat (LY450139)	22	++	Aβ42,Aβ38,Aβ40
Dibenzazepine (YO-01027)	40	+++	γ secretase
LY411575	45	++++	γ secretase
IMR-1A	0	++
IMR-1	7	+
FLI-06	13	+
Crenigacestat (LY3039478)	25	++++
DAPT	398	✔	Aβ
Limantrafin (CB-103)	4	✔
Compound E	0	✔	γ-secretase

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Tarextumab (Anti-NOTCH3) is an anti-Notch2/3 fully human IgG2 monoclonal antibody with anti-tumor activity. MW: 145.5 kD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1359940-55-8
Molecular Weight	145.5 kDa
Isotype	Human IgG2SA
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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