Stattic: Mechanism of Action

Stattic MOA:Targeting STAT3/JAK-STAT Pathway for Oncology

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Stattic is a specific small-molecule STAT3 inhibitor. It blocks JAK/STAT3 signaling by inhibiting STAT3 phosphorylation at Y705 and preventing its nuclear translocation, effectively suppressing tumor cell proliferation, migration, and invasion, while attenuating inflammation and fibrosis.

Primary Applications and Mechanism of Action