CAS No. 19983-44-9
Batch:
Purity:99.83
Chemical Structure
Check the
Stattic
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-nitro-1-benzothiophene 1,1-dioxide | |
|---|---|---|
| CAS Number | 19983-44-9 | |
| Molecular Formula |
C8H5NO4S |
|
| Molecular Weight (MW) | 211.19 | |
| SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] | |
| InChIKey | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
Biological Activity
Stattic is a nonpeptidic small-molecule inhibitor of STAT3 with an IC50 ofin cell-free assays, displaying high selectivity over STAT1. By binding to the STAT3 SH2 domain, Stattic selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Disruption of STAT3 signaling suppresses downstream pathways, thereby inhibiting cell growth and inducing apoptosis in STAT3-dependent cancer cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
42 mg/mL
(198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
42 mg/mL
(198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
125 mg/mL
(591.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
42 mg/mL
(198.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Stattic Mechanism of Action: STAT3 Inhibition in Cancer Cells Research
- Stattic Working Concentration | Cell Culture | Treatment
- Stattic Solubility in DMSO
- Stattic Stock Solution
- Stattic Storage
- Stattic Stability
- Stattic Combination Database
- Stattic Molecular Weight
- Stattic SMILES
- Stattic Chemical Structure (2D and 3D)
- Stattic IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.