CAS No. 124-20-9
Batch:
Purity:97
Chemical Structure
Check the
Spermidine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-(3-aminopropyl)butane-1,4-diamine | |
|---|---|---|
| CAS Number | 124-20-9 | |
| Molecular Formula |
C7H19N3 |
|
| Molecular Weight (MW) | 145.25 | |
| InChIKey | ATHGHQPFGPMSJY-UHFFFAOYSA-N |
Spermidine is a naturally occurring polyamine that acts as a potent inducer of cytoprotective macroautophagy. By inhibiting histone acetyltransferases, spermidine reduces histone H3 hyperacetylation, enhancing the expression of essential autophagy-related genes and promoting protein clearance. This sustained activation of autophagy suppresses oxidative stress, restores mitochondrial homeostasis, and extends lifespan in diverse model organisms. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
20 mg/mL
(137.69 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.