AMG 510 (Sotorasib): Selectivity & Specificity

AMG 510 (Sotorasib) is a potent inhibitor of KRASG12C (0.09 μM), KRAS (141.4 nM), SOS1. AMG 510 (Sotorasib) exhibits the greatest inhibitory potency toward KRASG12C (IC50 = 90 nM).