SMILES:
CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C
Chemical Structure
Check the
AMG 510 (Sotorasib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-yl-3-pyridinyl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one | |
|---|---|---|
| CAS Number | 2296729-00-3 | |
| Molecular Formula |
C30H30F2N6O3 |
|
| Molecular Weight (MW) | 560.59 | |
| SMILES | CC1CN(CCN1C2=NC(=O)N(C3=NC(=C(C=C32)F)C4=C(C=CC=C4F)O)C5=C(C=CN=C5C(C)C)C)C(=O)C=C | |
| InChIKey | NXQKSXLFSAEQCZ-SFHVURJKSA-N |
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(178.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
50 mg/mL
(89.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(178.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(178.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12.5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- AMG 510 (Sotorasib) Mechanism of Action: KRAS G12C Inhibition in Non-Small Cell Lung Cancer Cells Research
- AMG 510 (Sotorasib) Clinical Trials
- AMG 510 (Sotorasib): Selectivity & Specificity
- AMG 510 (Sotorasib) Working Concentration | Cell Culture | Treatment
- AMG 510 (Sotorasib) Solubility in DMSO
- AMG 510 (Sotorasib) Stock Solution
- AMG 510 (Sotorasib) Storage
- AMG 510 (Sotorasib) Stability
- AMG 510 (Sotorasib) Combination Database
- AMG 510 (Sotorasib) Molecular Weight
- AMG 510 (Sotorasib) CAS Number
- AMG 510 (Sotorasib) Chemical Structure (2D and 3D)
- AMG 510 (Sotorasib) IC50 for Cell-based and Cell-free Assays
- AMG 510 (Sotorasib) Sigma (SBR00089)? Try a better option.
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- AMG 510 (Sotorasib) Cayman (29465)? Try a better option.
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- AMG 510 (Sotorasib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.