AMG 510 (Sotorasib) is a potent, selective, and covalent KRAS G12C inhibitor. It affects MAPK and PI3K-AKT-mTOR signaling by covalently binding to the cysteine residue of GDP-bound KRAS to trap it in an inactive state, effectively inhibiting tumor cell proliferation.
AMG 510 (Sotorasib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for AMG 510 (Sotorasib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.