CAS No. 565-73-1
Batch:
Purity:98.03
Chemical Structure
Check the
Sodium oxamate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | sodium oxamate | |
|---|---|---|
| CAS Number | 565-73-1 | |
| Molecular Formula |
C2H2NNaO3 |
|
| Molecular Weight (MW) | 111.03 | |
| SMILES | C(=O)(C(=O)[O-])N.[Na+] | |
| InChIKey | RQVZIJIQDCGIKI-UHFFFAOYSA-M |
Sodium oxamate is a specific inhibitor of lactate dehydrogenase, selectively targeting lactate dehydrogenase A (LDH-A). By suppressing LDH-A activity, it disrupts glycolytic flux and downregulates the CDK1/cyclin B1 pathway, triggering G2/M cell cycle arrest. Furthermore, sodium oxamate enhances mitochondrial reactive oxygen species (ROS) generation, promoting mitochondrial dysfunction and inducing apoptotic cell death across various cancer models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 22 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 75 mg/mL (超声助溶) |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 22 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 22 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 22 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- Sodium oxamate Stock Solution
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- Sodium oxamate Combination Database
- Sodium oxamate Molecular Weight
- Sodium oxamate SMILES
- Sodium oxamate Chemical Structure (2D and 3D)
- Sodium oxamate IC50 for Cell-based and Cell-free Assays
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Note: Technical data last updated: Sep 1, 2026.