Clinical Trials

Sitagliptin is supported by numerous clinical trials spanning Phase I through Phase IV evaluations across completed, active, and upcoming recruitment statuses. These studies assess the compound as both monotherapy and combination therapy for metabolic conditions—such as type 2 diabetes mellitus, type 1 diabetes, pre-diabetes, and severe obesity—as well as for pharmacokinetic assessments in healthy subjects. Research is conducted by diverse sponsors ranging from pharmaceutical corporations to academic institutions.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06813014 NOT_YET_RECRUITING
Diabetes
University of Maryland, Baltimore
2026-12 PHASE4
NCT07365592 RECRUITING
Colorectal Cancer
Second Affiliated Hospital, Zhejiang University, School of Medicine
2026-04-09 PHASE1; PHASE2
NCT07108985 NOT_YET_RECRUITING
Diabetes Mellitus, Type 2; Hyperglycemia; Insulin Resistance
Yonsei University
2025-09 PHASE4
NCT07541781 RECRUITING
Glioma; Glioblastoma; Recurrent Glioma; Recurrent Glioblastoma; Grade 4 Malignant Glioma of Brain (Disorder)
Kailin Yang, MD, PhD
2026-06-11 PHASE1
NCT06246799 RECRUITING
Type 2 Diabetes (Adult Onset)
The University of Texas Health Science Center at San Antonio
2024-11-07 PHASE3
NCT07804381 NOT_YET_RECRUITING
Parkinson Disease
Yonsei University
2026-12-15 PHASE2
NCT06587698 RECRUITING
Polycystic Ovarian Syndrome
Peking University Third Hospital
2024-08-21
NCT07717242 RECRUITING
Bladder Urothelial Carcinoma; Bladder Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
2026-07-01 PHASE2
NCT07634380 RECRUITING
Advanced Renal Cell Carcinoma; Advanced Melanoma
Fernando Maciel Barbosa
2026-05-14 PHASE1
NCT07436663 NOT_YET_RECRUITING
Breast Cancer
Tanta University
2026-02-01 PHASE4
NCT07365358 NOT_YET_RECRUITING
Diabete Type 2
Chong Kun Dang Pharmaceutical
2026-03 PHASE4
NCT07003542 RECRUITING
Glioblastoma; Brain Tumor
Case Comprehensive Cancer Center
2026-03-16 PHASE2
NCT07073768 ENROLLING_BY_INVITATION
Diabetes Mellitus Type 2; Glycemic Control for Diabetes Mellitus
Khyber Medical College, Peshawar
2025-07-01 PHASE3
NCT05195944 ENROLLING_BY_INVITATION
Liver Transplant; Complications; Diabetes Mellitus; NASH - Nonalcoholic Steatohepatitis; NAFLD
University Health Network, Toronto
2022-10-26 PHASE4
NCT07711171 RECRUITING
Type 2 Diabetes Mellitus; Cognitive Impairment
Fudan University
2024-08-19 PHASE4
NCT06972732 RECRUITING
Type 2 Diabetes
Boryung Pharmaceutical Co., Ltd
2025-06-11 PHASE4
NCT05947825 ENROLLING_BY_INVITATION
PDAC - Pancreatic Ductal Adenocarcinoma
Tianjin Medical University Cancer Institute and Hospital
2023-07-01 PHASE2
NCT07567781 COMPLETED
Healthy Volunteers
AbbVie
2026-04-30 PHASE1
NCT06851962 COMPLETED
Diabetes Mellitus Type 2
Fundación para la Investigación del Hospital Clínico de Valencia
2025-05-26 PHASE4
NCT07374328 RECRUITING
Type 2 Diabetes
Second Affiliated Hospital of Guangzhou Medical University
2025-06-01 PHASE1; PHASE2
NCT07452913 ENROLLING_BY_INVITATION
Type 2 Diabetes Mellitus
Bahria University
2026-01-01 PHASE4
NCT06329882 RECRUITING
Diabetes Mellitus, Type 2
Mostafa Bahaa
2024-03-30 PHASE1; PHASE2
NCT07763964 COMPLETED
Bioequivalance
ADIUM
2025-12-08
NCT07763951 COMPLETED
Bioequivalance
ADIUM
2025-12-03
NCT07763912 COMPLETED
Bioequivalence
ADIUM
2025-11-24
NCT05219409 NOT_YET_RECRUITING
Type 1 Diabetes
University of Milan
2023-07 PHASE2; PHASE3
NCT05895201 WITHDRAWN
Bone Marrow Transplant Complications; Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia, Adult; Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia
Indiana University
2023-11 PHASE1; PHASE2
NCT07763899 COMPLETED
Bioequivalance
ADIUM
2025-11-19
NCT07531108 COMPLETED
Diabetes Mellitus, Type 2
Hawler Medical University
2024-11-15 PHASE4
NCT05833958 WITHDRAWN
Type 2 Diabetes
George Medicines PTY Limited
2024-09 PHASE2
NCT07439536 COMPLETED
Liver Cirrhosis With Diabetes
Kafrelsheikh University
2024-07-01 PHASE4
NCT04495881 UNKNOWN
Type 2 Diabetes
Beijing Chao Yang Hospital
2020-01-01 PHASE4
NCT07172269 COMPLETED
Diabete Mellitus; Type 2 Diabetes; Obesity Type 2 Diabetes Mellitus; Dyslipidemia in Patients With Diabetes Mellitus; Insulin Resistance
Mais Qais Hbeeb
2024-09-15
NCT06187285 COMPLETED
Type 2 Diabetes
Medanta, The Medicity, India
2024-01-01
NCT05972928 COMPLETED
Polycystic Ovary Syndrome
Beni-Suef University
2024-08-07 PHASE2; PHASE3
NCT06759922 COMPLETED
Type 2 Diabetes Mellitus
Bahria University
2025-01-01 PHASE4
NCT04323189 ACTIVE_NOT_RECRUITING
Genetics Disease; Type2 Diabetes; Heart Failure
University of Pennsylvania
2020-08-26 PHASE4
NCT06263673 COMPLETED
Lewy Body Dementia; Parkinson Disease
Mayo Clinic
2024-05-07 PHASE4
NCT04409795 COMPLETED
Type 1 Diabetes; Monogenic Diabetes
Joslin Diabetes Center
2021-08-26 PHASE2; PHASE3
NCT06147518 UNKNOWN
Compensated Cirrhosis; Decompensated Cirrhosis
Institute of Liver and Biliary Sciences, India
2023-12-20
NCT05367063 COMPLETED
Type 2 Diabetes; Cardiovascular Risk
Shanghai Zhongshan Hospital
2022-01-05 PHASE4
NCT06952231 COMPLETED
Diabetes Mellitus
University of Lahore
2024-05-21 PHASE3
NCT05042505 COMPLETED
Diabetes Mellitus; Liver Transplant; Complications
Medanta, The Medicity, India
2022-01-01
NCT03738878 TERMINATED
Hypertension
Vanderbilt University Medical Center
2018-11-15 PHASE4
NCT07083232 COMPLETED
Diabetic; Myocardial Infarction
Al-Azhar University
2024-10-30 PHASE4
NCT06054815 COMPLETED
NON-ALCOHOLIC STEATOHEPATITIS
NeuroBo Pharmaceuticals Inc.
2023-09-14 PHASE2
NCT04271189 COMPLETED
Newly Diagnosed Type 2 Diabetes
Azienda Ospedaliero-Universitaria di Parma
2020-09-01 PHASE3
NCT06515652 UNKNOWN
Metabolic Syndrome
Hamdard University
2023-09-01
NCT06233201 UNKNOWN
Healthy Subjects
Bio-innova Co., Ltd
2024-06-04 PHASE1
NCT06613750 COMPLETED
Type 2 Diabetes Mellitus; Glucotoxicity
Zhibin Xu
2024-06-01 PHASE4
NCT06233240 UNKNOWN
Healthy Subjects
Bio-innova Co., Ltd
2024-04-30 PHASE1
NCT06204107 COMPLETED
Type 2 Diabetes Mellitus
Chong Kun Dang Pharmaceutical
2023-11-21 PHASE1
NCT07076056 COMPLETED
Type 2 Diabetes
Daewon Pharmaceutical Co., Ltd.
2022-10-27 PHASE3
NCT04304261 COMPLETED
Diabetes Mellitus, Type 2; Cognitive Functions Confusion
Third Military Medical University
2021-07-01 PHASE3
NCT05386186 UNKNOWN
Diabetes Mellitus, Type 2; Severe Insulin Deficient Diabetes
Peking University People's Hospital
2022-01-01 PHASE4
NCT05667220 UNKNOWN
Type 2 Diabetes
Beijing Chao Yang Hospital
2022-12-01 PHASE4
NCT06770894 COMPLETED
Osteoporosis; Bone Loss, Postmenopausal; Diabetes Mellitus Type 2
Azienda Policlinico Umberto I
2019-09-24 PHASE3
NCT02879409 ACTIVE_NOT_RECRUITING
Diabetes Mellitus Type 2
Weill Cornell Medical College in Qatar
2016-11
NCT05149365 COMPLETED
Acute-graft-versus-host Disease; Allogeneic Hematopoietic Stem Cell Transplantation
The First Affiliated Hospital of Soochow University
2021-12-22 PHASE3
NCT05579119 COMPLETED
Type 2 Diabetes
Hospital de Especialidades, Centro Medico Nacional "La Raza", Instituto Mexicano del Seguro Social
2022-07-06 PHASE4
NCT05219409 Not yet recruiting
Type 1 Diabetes
University of Milan
2023-07 Phase 2|Phase 3
NCT06115460 COMPLETED
Type 1 Diabetic Nephropathy
Ain Shams University
2022-03-01 PHASE3
NCT05900531 COMPLETED
Obesity
Kallyope Inc.
2022-09-21 PHASE1
NCT07679711 COMPLETED
Healthy Volunteers
The Affiliated Hospital of Qingdao University
2023-02-14 PHASE1
NCT06124547 COMPLETED
Bioequivalence; Diabetes Mellitus, Type 2
Galenicum Health
2023-01-16 PHASE1
NCT06124495 COMPLETED
Bioequivalence; Diabetes Mellitus, Type 2
Galenicum Health
2023-01-13 PHASE1
NCT05798715 COMPLETED
Healthy
Genuine Research Center, Egypt
2022-11-29 PHASE1
NCT05353673 UNKNOWN
Immune Thrombocytopenia; Blood Coagulation Disorders; Thrombocytopenia; Physiological Effects of Drugs
Peking University People's Hospital
2021-06-01 PHASE2
NCT06124573 COMPLETED
Bioequivalence; Diabetes Mellitus, Type 2
Galenicum Health
2022-11-07 PHASE1
NCT04982705 UNKNOWN
Type 2 Diabetes
IlDong Pharmaceutical Co Ltd
2021-07-07 PHASE1
NCT06124560 COMPLETED
Bioequivalence; Diabetes Mellitus, Type 2
Galenicum Health
2022-10-28 PHASE1
NCT03076112 COMPLETED
Type 2 Diabetes Mellitus
Seoul National University Bundang Hospital
2017-04-25 PHASE3
NCT04161430 COMPLETED
Type 2 Diabetes Mellitus
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
2020-01-02 PHASE3
NCT05266404 COMPLETED
Healthy Volunteers (Intended Indication: Type 2 Diabetes Mellitus)
AstraZeneca
2022-03-21 PHASE1
NCT05167513 COMPLETED
Quality of Life; Type 2 Diabetes; Metformin+Sitagliptin
Getz Pharma
2021-01-01 PHASE4
NCT04365517 UNKNOWN
Covid19; Diabetes Mellitus, Type 2; CKD
University of Milan
2021-12-29 PHASE3
NCT04298684 UNKNOWN
Diabetes Mellitus, Type 2; Thyroid Nodule (Benign)
Centre Hospitalier Universitaire de la Guadeloupe
2021-01-01 PHASE4
NCT02315287 UNKNOWN
Type 2 Diabetes
Seoul National University Bundang Hospital
2014-09 PHASE4
NCT04448587 UNKNOWN
Graft Vs Host Disease
Rabin Medical Center
2020-10-01 PHASE2
NCT05236998 COMPLETED
Healthy Subjects
SK Chemicals Co., Ltd.
2021-11-03 PHASE1
NCT02338921 COMPLETED
Type 2 Diabetes
Seoul National University Bundang Hospital
2015-01 PHASE4
NCT05403281 Completed
Healthy Subjects
Dong Wha Pharmaceutical Co. Ltd.
2021-11-05 Phase 1
NCT04017832 COMPLETED
Diabetes Mellitus, Type 2
Novo Nordisk A/S
2019-07-29 PHASE3
NCT05359341 COMPLETED
Diabete Type 2
Sadat City University
2020-09-20
NCT02697253 WITHDRAWN
Obesity
Icahn School of Medicine at Mount Sinai
2016-01 PHASE2
NCT04268563 UNKNOWN
Polycystic Ovary Syndrome; Infertility; ART
Shahid Beheshti University of Medical Sciences
2020-01-10 PHASE1; PHASE2
NCT03101930 COMPLETED
Obesity; PreDiabetes
Vanderbilt University Medical Center
2017-05-01 PHASE4
NCT05035849 COMPLETED
Type 2 Diabetes
Nanjing First Hospital, Nanjing Medical University
2020-01-30
NCT01794143 COMPLETED
Type 2 Diabetes; Comparative Effectiveness of Glycemia-lowering Medications
GRADE Study Group
2013-05 PHASE3
NCT04287387 UNKNOWN
Type2 Diabetes Mellitus
Peking Union Medical College Hospital
2020-03-02 PHASE4
NCT03893526 COMPLETED
Type2 Diabetes
University of Copenhagen
2019-01-25 PHASE4
NCT04801199 COMPLETED
Uncontrolled Type 2 Diabetes Mellitus
Cadila Pharnmaceuticals
2020-01-26 PHASE3
NCT02653209 COMPLETED
Type 2 Diabetes
Royal Devon and Exeter NHS Foundation Trust
2016-11-01 PHASE4
NCT04810507 COMPLETED
Type 2 Diabetes
JW Pharmaceutical
2018-11-09 PHASE4
NCT04916093 COMPLETED
Diabetes Mellitus, Type 2
Beni-Suef University
2019-12-20 PHASE4
NCT01928199 COMPLETED
Posttransplant Diabetes Mellitus
Washington University School of Medicine
2013-09 PHASE4
NCT03646721 COMPLETED
Diabetes Mellitus, Type 2
Dong-A ST Co., Ltd.
2018-08-29 PHASE1
NCT02130687 COMPLETED
Type 2 Diabetes Mellitus; Hypertension
Vanderbilt University
2014-06
NCT02377388 COMPLETED
Platelet Aggregation During Acute Myocardial Infarction
University of Sao Paulo General Hospital
2017-02-07 PHASE3
NCT03659461 COMPLETED
Type 2 Diabetes Mellitus; PreDiabetes
National University of Malaysia
2017-10-01
NCT01879228 COMPLETED
Cystic Fibrosis; Pancreatic Insufficiency
University of Pennsylvania
2013-06
NCT00813228 COMPLETED
Diabetes Mellitus Type 1; Diabetes Mellitus Type 2
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2009-01-06 PHASE1
NCT01485614 COMPLETED
Diabetes Mellitus; Type 2 Diabetes
Merck Sharp & Dohme LLC
2012-02-10 PHASE3
NCT01760447 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2011-12-07 PHASE3
NCT03790839 COMPLETED
Patients
Hua Medicine Limited
2019-01-31 PHASE1
NCT02917031 COMPLETED
Type 2 Diabetes Mellitus; Heart Failure
AstraZeneca
2017-01-10 PHASE4
NCT04061473 COMPLETED
Diabetes After Total Pancreatectomy
University Hospital, Gentofte, Copenhagen
2019-04-02
NCT03208465 COMPLETED
Diabetes Mellitus; Coronary Disease
CHEOL WHAN LEE, M.D., Ph.D
2017-08-07 PHASE4
NCT02122380 COMPLETED
Polycystic Ovary Syndrome
Vanderbilt University
2016-02 PHASE4
NCT03359590 COMPLETED
Pharmacological Action
Profil Institut für Stoffwechselforschung GmbH
2018-03-21 PHASE2
NCT02802644 UNKNOWN
Acute Coronary Syndrome; Diabetes Mellitus, Type 2
Chung-Ang University
2016-06 PHASE4
NCT03602638 UNKNOWN
Atherosclerosis Type 2 Diabetes Mellitus Dipeptidyl Peptidase-4 Inhibitor GLP-1
Chinese PLA General Hospital
2018-10-01 PHASE4
NCT03061214 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2017-08-28 PHASE3
NCT02683525 COMPLETED
Graft vs Host Disease; Hematopoietic Stem Cell Transplantation
Sherif S. Farag
2016-02-03 PHASE2
NCT03717688 COMPLETED
Diabetes; Heart Failure
Nicolai Jacob Wewer Albrechtsen
2018-05-17 PHASE4
NCT03790839 Completed
Patients
Hua Medicine Limited
2019-01-31 Phase 1
NCT01471808 COMPLETED
Diabetes Mellitus, Type 2
Sun Yat-sen University
2011-10 PHASE4
NCT02556918 COMPLETED
Hyperglycemia
Emory University
2016-01 PHASE4
NCT01140438 COMPLETED
Diabetes
Norwegian University of Science and Technology
2009-03
NCT03115112 COMPLETED
Type 2 Diabetes Mellitus
Theracos
2017-10-12 PHASE3
NCT03267576 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2017-10-27 PHASE4
NCT02940184 UNKNOWN
Physiology
University of Copenhagen
2016-06
NCT02623998 COMPLETED
Type 2 Diabetes Mellitus
Population Health Research Institute
2016-07-09 PHASE3
NCT02650427 COMPLETED
Hepato Carcinoma
Institut National de la Santé Et de la Recherche Médicale, France
2016-02 PHASE1
NCT02920918 COMPLETED
Heart Failure, Systolic; Diabetes Mellitus, Type 2
Virginia Commonwealth University
2016-10 PHASE4
NCT02689362 COMPLETED
Diabetes Mellitus, Type 2
Eurofarma Laboratorios S.A.
2017-08-08 PHASE2
NCT01951339 COMPLETED
Type 2 Diabetes; Cardiovascular Disease
University of Colorado, Denver
2013-10
NCT04877106 COMPLETED
Healthy Subjects
The Affiliated Hospital of Qingdao University
2018-04-07 PHASE1
NCT02882477 UNKNOWN
Diabetes Mellitus; Iron Metabolism Disorders; Gastroduodenal Ulcer; Optic Atrophy; Sensorineural Hearing Loss; Platelet Dysfunction
Hadassah Medical Organization
2016-12 PHASE2; PHASE3
NCT05549583 COMPLETED
Bioequivalence; Type 2 Diabetes
Galenicum Health
2018-04-15 PHASE1
NCT03115099 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
2017-05-31 PHASE1
NCT02683187 COMPLETED
Healthy
David D'Alessio, M.D.
2017-03-01 PHASE1
NCT03359590 Completed
Pharmacological Action
Profil Institut für Stoffwechselforschung GmbH|Merck Sharp & Dohme LLC
2018-03-21 Phase 2
NCT02849080 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2016-09-20 PHASE3
NCT02060383 COMPLETED
Cushing's Disease; Acromegaly
Novartis Pharmaceuticals
2014-05-23 PHASE4
NCT02791490 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2016-06-16 PHASE3
NCT02738879 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2016-05-09 PHASE3
NCT03108521 COMPLETED
Diabetes Mellitus
Sichuan Provincial People's Hospital
2016-04-21 PHASE4
NCT02330406 COMPLETED
Dipeptidyl-Peptidase 4 Inhibitors; LDL Cholesterol; Glycosylated Hemoglobin; Diabetes Mellitus; Coronary Disease
Institute for Clinical Effectiveness, Japan
2015-04 PHASE4
NCT02576288 COMPLETED
Atherosclerosis; Inflammation
University of Southern California
2016-01 PHASE2
NCT01336322 COMPLETED
Pre-diabetes
University of Pisa
2011-05 PHASE2
NCT02743260 COMPLETED
Healthy
University of Cologne
2016-04 PHASE4
NCT03593135 COMPLETED
Randomized Controlled Trial; Diabetes Mellitus
Sheikh Zayed Federal Postgraduate Medical Institute
2017-07-15
NCT05549570 COMPLETED
Bioequivalence; Diabetes Mellitus, Type 2
Galenicum Health
2017-10-22 PHASE1
NCT02532855 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2015-10-20 PHASE3
NCT02567994 COMPLETED
Type 2 Diabetes Mellitus
Handok Inc.
2015-04 PHASE3
NCT02536248 COMPLETED
Type 2 Diabetes Mellitus
Laval University
2015-08-01 PHASE3
NCT01856907 COMPLETED
Disorder of Glucose Regulation
Woman's
2013-09-28 PHASE4
NCT02043054 COMPLETED
Type 2 Diabetes Mellitus; Cardiovascular Disease
University of Leicester
2013-12-16 PHASE3
NCT02256189 COMPLETED
Type 2 Diabetes
Lund University
2015-04 PHASE4
NCT02301806 UNKNOWN
Type 2 Diabetes
Dokkyo Medical University
2015-01 PHASE4
NCT02089438 COMPLETED
Type 2 Diabetes
Lund University
2014-05 PHASE4
NCT02639637 COMPLETED
Type 2 Diabetes Mellitus
Vanderbilt University
2015-12 PHASE4
NCT01701973 COMPLETED
Obesity
Vanderbilt University
2013-01 PHASE4
NCT01999218 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2013-12-16 PHASE3
NCT02527993 COMPLETED
Hypoglycemia; Obesity; Surgery
Zealand University Hospital
2015-10 PHASE4
NCT03125694 COMPLETED
Uncontrolled Type 2 Diabetes Mellitus
Tehran University of Medical Sciences
2015-02-01 PHASE3
NCT02147925 COMPLETED
Non-alcoholic Fatty Liver Disease
Sun Yat-sen University
2014-08 PHASE4
NCT02741687 COMPLETED
Hyperglycemia
Emory University
2016-06 PHASE4
NCT00967798 TERMINATED
Cystic Fibrosis; Prediabetes
Emory University
2010-05 PHASE3
NCT02564211 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2015-10-26 PHASE3
NCT02956044 COMPLETED
Type2 Diabetes Mellitus
Theracos
2016-11 PHASE1
NCT02675335 WITHDRAWN
Diabetic Foot
Wolfgang-Michael Franz
2016-03 PHASE3
NCT02607865 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2016-02-15 PHASE3
NCT02655757 COMPLETED
Atherosclerosis; Type 2 Diabetes Mellitus
Li Bo
2015-12 PHASE4
NCT01984606 WITHDRAWN
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2015-01 PHASE3
NCT02647320 COMPLETED
Type 2 Diabetes Mellitus
Daiichi Sankyo
2016-01 PHASE2
NCT02452632 COMPLETED
Type 2 Diabetes Mellitus
Astellas Pharma Korea, Inc.
2015-06-22 PHASE3
NCT02324010 COMPLETED
Gastroparesis; Diabetes Mellitus
Royal Adelaide Hospital
2015-07 PHASE2
NCT02173457 COMPLETED
Type 2 Diabetes
Chipscreen Biosciences, Ltd.
2014-09 PHASE3
NCT02373865 TERMINATED
Diabetes Mellitus Type 2
GWT-TUD GmbH
2015-09 PHASE4
NCT02513771 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2015-09 PHASE2
NCT01703637 UNKNOWN
Type 2 Diabetes Mellitus
Lin Liao
2012-10
NCT02347501 COMPLETED
Psoriasis
University College Dublin
2013-11 PHASE2
NCT02480465 UNKNOWN
Diabetes Mellitus, Type 2
Chong Kun Dang Pharmaceutical
2015-01 PHASE4
NCT02443402 COMPLETED
Coronary Artery Disease
Emory University
2016-01 PHASE4
NCT02577003 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2015-11-09 PHASE3
NCT02577016 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2015-11-05 PHASE3
NCT01824264 WITHDRAWN
Type 2 Diabetes Mellitus
Novartis Pharmaceuticals
2015-11 PHASE2
NCT03122041 COMPLETED
PCOS
University Medical Centre Ljubljana
2016-08 PHASE4
NCT02900417 UNKNOWN
Type 2 Diabetes
Second Affiliated Hospital of Soochow University
2016-09
NCT02294084 COMPLETED
Neoplasms, Adipose Tissue
Ingrid Jazet
2014-03 PHASE4
NCT02512523 COMPLETED
Type 2 Diabetes Mellitus
Handok Inc.
2015-08-27 PHASE4
NCT02284893 COMPLETED
Type 2 Diabetes
AstraZeneca
2014-09-09 PHASE3
NCT02363335 COMPLETED
Healthy Volunteers
National Institute on Aging (NIA)
2015-02-13 PHASE1
NCT02628392 COMPLETED
Type2 Diabetes Mellitus
Daiichi Sankyo Co., Ltd.
2015-11
NCT02685345 COMPLETED
Type 2 Diabetes Mellitus
Daiichi Sankyo Co., Ltd.
2016-01 PHASE2
NCT01720264 COMPLETED
Acute Myeloid Leukemia; Acute Lymphoid Leukemia; Hematopoetic Myelodysplasia; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin
Sherif S. Farag
2012-11-02 PHASE2
NCT02941445 COMPLETED
Polycystic Ovary Syndrome; Body Weight
University Medical Centre Ljubljana
2015-10 PHASE4
NCT01512797 COMPLETED
Type 2 Diabetes Mellitus
Blandine Laferrere
2012-07
NCT01970462 TERMINATED
Diabetes Mellitus, Type 2; Hyperglycemia
Kathleen Dungan
2014-01 PHASE4
NCT02405260 COMPLETED
Diabetes Mellitus, Type 2
vTv Therapeutics
2015-03 PHASE2
NCT02127047 COMPLETED
Diabetes Mellitus Type 1
University Hospital, Basel, Switzerland
2013-11 PHASE2
NCT02036515 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2014-03-12 PHASE3
NCT01721382 COMPLETED
Cystic Fibrosis
Nemours Children's Clinic
2012-11 PHASE1
NCT02099110 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2014-04-22 PHASE3
NCT02312063 COMPLETED
Diabetes Mellitus, Type 2
Kansai Electric Power Hospital
2015-02 PHASE4
NCT02336659 COMPLETED
Severe Obesity
Hvidovre University Hospital
2014-04
NCT02827890 COMPLETED
Diabetes Mellitus Type 2
Chong Kun Dang Pharmaceutical
2016-04 PHASE1
NCT02824874 COMPLETED
Diabetes Mellitus, Type II
Chong Kun Dang Pharmaceutical
2016-04 PHASE1
NCT01845831 COMPLETED
Type 2 Diabetes
Emory University
2013-08 PHASE4
NCT02226003 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2014-09-23 PHASE3
NCT02048904 TERMINATED
Type 2 Diabetes; Microalbuminuria
University of Missouri-Columbia
2014-01 PHASE4
NCT02328040 COMPLETED
Diabetes Mellitus, Type 1
Albert Einstein College of Medicine
2014-09 PHASE1
NCT01859793 COMPLETED
Diabetes; Atherosclerosis
Medical College of Wisconsin
2013-06 PHASE4
NCT01963845 COMPLETED
Non-alcoholic Fatty Liver Disease
University of California, San Diego
2014-01 PHASE2
NCT02444364 WITHDRAWN
Type 2 Diabetes
University of Missouri-Columbia
2015-05 EARLY_PHASE1
NCT01991197 COMPLETED
Psoriasis; Type 2 Diabetes Mellitus
University College Dublin
2014-04 PHASE2
NCT02318693 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2015-02-04 PHASE4
NCT05480007 COMPLETED
NAFLD
Shanghai 10th People's Hospital
2011-01-30
NCT02443922 UNKNOWN
Type 2 Diabetes
Foundation for the National Institutes of Health
2015-06
NCT02263677 WITHDRAWN
Type 2 Diabetes; Non-alcoholic Fatty Liver Disease
University of Missouri-Columbia
2014-03 PHASE4
NCT01718093 COMPLETED
Type 1 Diabetes
Baylor College of Medicine
2012-10 PHASE4
NCT01901861 COMPLETED
Type 2 Diabetes
Lund University
2013-07
NCT02254291 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2014-10-02 PHASE3
NCT01073826 COMPLETED
Diabetes Mellitus, Type 2; Obesity
University of Zurich
2010-02
NCT02200991 COMPLETED
Type 2 Diabetes Mellitus
Sanofi
2014-08 PHASE4
NCT01930188 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2013-12-02 PHASE3
NCT02072096 TERMINATED
Diabetes Mellitus, Type 2
Eli Lilly and Company
2014-02 PHASE4
NCT02025907 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2014-02 PHASE4
NCT02111096 TERMINATED
Diabetes Mellitus, Type 2
Eli Lilly and Company
2014-04 PHASE2
NCT01744236 COMPLETED
Type 2 Diabetes
Amsterdam UMC, location VUmc
2013-04 PHASE4
NCT00964184 COMPLETED
Diabetes Mellitus, Type 2
Diabetes Foundation, India
2009-09 PHASE4
NCT01863147 COMPLETED
Newly Diagnosed Type 2 Diabetes; Coronary Artery Disease
Wuhan General Hospital of Guangzhou Military Command
2013-07 PHASE4
NCT01186562 COMPLETED
Pancreatitis; Diabetes
University of Minnesota
2010-08 PHASE4
NCT01455870 COMPLETED
Type 2 Diabetes
Intarcia Therapeutics
2013-05 PHASE3
NCT02493959 COMPLETED
Healthy
Hvidovre University Hospital
2014-05 EARLY_PHASE1
NCT01907854 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2013-12-02 PHASE4
NCT02406950 UNKNOWN
Healthy
Kyunghee University Medical Center
2015-02 PHASE3
NCT02250794 WITHDRAWN
Type 2 Diabetes Mellitus
Rush University Medical Center
2014-10 PHASE4
NCT01709305 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-11-08 PHASE4
NCT01260246 TERMINATED
Type 2 Diabetes; Nonalcoholic Steatohepatitis
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
2010-12
NCT00790205 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-12-10 PHASE3
NCT01530178 COMPLETED
Diabetes Mellitus, Type 1
Albert Einstein College of Medicine
2011-11 PHASE4
NCT02386943 UNKNOWN
Type 2 Diabetes
Shanghai Jiao Tong University School of Medicine
2013-12 PHASE4
NCT01847144 COMPLETED
Type 2 Diabetes
Royal Devon and Exeter NHS Foundation Trust
2013-04 PHASE4
NCT02202161 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2014-08-27 PHASE2
NCT02015910 TERMINATED
Type II Diabetes
Georgetown University
2014-01 PHASE4
NCT01183104 COMPLETED
Type 2 Diabetes
Japan Association for Diabetes Education and Care
2010-08
NCT01841697 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2013-06-13 PHASE3
NCT02949193 COMPLETED
Type 2 Diabetes Mellitus
Dong-A ST Co., Ltd.
2013-05 PHASE3
NCT02008682 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2013-12 PHASE4
NCT01552694 COMPLETED
Inflammation; Macrophage Infiltration; Cardiovascular Disease
Washington University School of Medicine
2012-10 PHASE3
NCT01686932 COMPLETED
Diabetes Mellitus Type 2
Novartis Pharmaceuticals
2012-11 PHASE4
NCT01449747 COMPLETED
Type 2 Diabetes Mellitus
The Catholic University of Korea
2011-12 PHASE4
NCT01890629 COMPLETED
Type 2 Diabetes Mellitus
LG Life Sciences
2013-05 PHASE4
NCT01610154 COMPLETED
Insulin Secretion; Insulin Resistance
Guangwei Li
2012-10 PHASE4
NCT01488279 COMPLETED
Pre-diabetes; Impaired Fasting Glucose; Impaired Glucose Tolerance
University of Vermont
2012-09
NCT01455909 WITHDRAWN
Type 2 Diabetes
Intarcia Therapeutics
2013-02 PHASE3
NCT01590797 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-07-10 PHASE3
NCT01590771 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-07-09 PHASE3
NCT01895569 UNKNOWN
Type 2 Diabetes Mellitus
University of Pavia
2013-06 PHASE4
NCT01155284 COMPLETED
Type 1 Diabetes
Sanford Health
2010-08 PHASE2
NCT01341717 COMPLETED
Diabetes Mellitus, Type 2
Jothydev's Diabetes and Research Centre
2012-02 PHASE4
NCT01557504 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-07-18 PHASE1
NCT01703221 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-10-24 PHASE3
NCT01936025 COMPLETED
Type 2 Diabetes Mellitus
Profil Institut für Stoffwechselforschung GmbH
2013-10 PHASE2
NCT01937598 COMPLETED
Type 2 Diabetes
Michael A. Nauck
2013-08 PHASE3
NCT01652729 COMPLETED
Diabetes Type 2
AstraZeneca
2013-02 PHASE3
NCT01785043 COMPLETED
DIABETES Mellitus Type 2 Not Well Controlled
Anna Cruceta
2013-03 PHASE4
NCT02749032 COMPLETED
Type 2 Diabetes
Michael A. Nauck
2011-11 PHASE1
NCT01834274 TERMINATED
Diabetes Mellitus, Type 2
Takeda
2013-06 PHASE3
NCT01549964 TERMINATED
Glycemic Control
Takeda
2012-04 PHASE3
NCT01099618 COMPLETED
Ketosis Prone Diabetes; Diabetes Ketoacidosis; Hyperglycemia
Dawn Smiley MD
2010-03 PHASE4
NCT02192853 COMPLETED
Type 2 Diabetes Mellitus
University Hospital, Gentofte, Copenhagen
2013-05 PHASE4
NCT01038648 WITHDRAWN
Type 2 Diabetes
India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
2011-12 PHASE3
NCT01829464 TERMINATED
Diabetes
Takeda
2013-05 PHASE3
NCT01567540 TERMINATED
Hepatitis C
Institut National de la Santé Et de la Recherche Médicale, France
2013-03 PHASE1
NCT00659711 COMPLETED
Type 2 Diabetes
University at Buffalo
2008-03
NCT01717911 UNKNOWN
Type 2 Diabetes
Taipei Veterans General Hospital, Taiwan
2010-09 PHASE4
NCT01678820 TERMINATED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-10-10 PHASE3
NCT00853944 TERMINATED
Islet Transplantation
University of British Columbia
2009-07 PHASE3
NCT00993187 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2010-05-04 PHASE4
NCT01519674 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2012-06 PHASE4
NCT01741103 WITHDRAWN
Diabetes Type I
University at Buffalo
2011-06
NCT01619332 COMPLETED
Type II Diabetes
Novartis Pharmaceuticals
2012-03 PHASE1; PHASE2
NCT01751321 UNKNOWN
Type 2 Diabetes
Research Clinical Centre of the Russian Railways, JSC
2013-05
NCT01413542 COMPLETED
Hypertension; Diabetes Type 2
Vanderbilt University
2011-11
NCT01462266 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-01-13 PHASE3
NCT01702298 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-12-07 PHASE3
NCT01529541 COMPLETED
Type 2 Diabetes Mellitus
JW Pharmaceutical
2011-05 PHASE3
NCT01642108 UNKNOWN
Type 2 Diabetes
Niigata Medical Center
2012-07
NCT01600703 COMPLETED
Hyperlipidemia
University Health Network, Toronto
2012-07 PHASE2; PHASE3
NCT01820104 COMPLETED
Healthy
Xijing Hospital
2013-03 PHASE1
NCT01289990 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2011-02 PHASE3
NCT01177384 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2011-01-25 PHASE3
NCT01545388 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-02-23 PHASE3
NCT01334229 COMPLETED
Type 2 Diabetes Mellitus
Laval University
2011-04 PHASE3
NCT01337440 UNKNOWN
Type 2 Diabetes Mellitus; Chronic Liver Disease
Kanazawa University
2010-04 PHASE4
NCT01475461 COMPLETED
Type 2 Diabetes Mellitus
Pfizer
2011-11 PHASE2
NCT01076088 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2010-11-15 PHASE3
NCT01582308 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2012-06-21 PHASE1
NCT01477853 TERMINATED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2011-10-24 PHASE3
NCT01660386 UNKNOWN
Type 2 Diabetes
Shanghai Jiao Tong University School of Medicine
2012-07 PHASE4
NCT00683735 COMPLETED
Diabetes
Michael A. Nauck
2009-02 PHASE2; PHASE3
NCT00775684 COMPLETED
Pre-diabetes; Type 2 Diabetes
University of Pennsylvania
2008-10
NCT00862719 COMPLETED
Leukemia, Myeloid, Acute; Acute Lymphoblastic Leukemia; Myelodysplasia; Leukemia, Myelogenous, Chronic; Lymphoma, Non-Hodgkin
Indiana University
2009-03 PHASE2
NCT00451113 COMPLETED
Type 2 Diabetes
University of British Columbia
2006-11 PHASE2
NCT01098539 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2010-05 PHASE3
NCT01189890 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2010-08-16 PHASE3
NCT01376323 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2011-07-13 PHASE2
NCT01414920 COMPLETED
Diabetes Mellitus, Type 2
Takeda
2011-08 PHASE2
NCT01374568 TERMINATED
Type 2 Diabetes Mellitus
University of Alabama at Birmingham
2010-07 PHASE4
NCT01159847 COMPLETED
Type 1 Diabetes
European Foundation for the Study of Diabetes
2010-01 PHASE1; PHASE2
NCT00721552 COMPLETED
Diabetes Mellitus; Steroid Diabetes; Glucocorticoid-induced Diabetes; Beta-cell Function
Amsterdam UMC, location VUmc
2008-10
NCT01272583 COMPLETED
Type 1 Diabetes; Hypoglycemia
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
2011-03
NCT00740363 COMPLETED
Glucose Intolerance
University of Oslo School of Pharmacy
2008-09 PHASE4
NCT01398592 COMPLETED
Diabetes Mellitus Type 2
Novartis Pharmaceuticals
2011-06 PHASE4
NCT00650143 COMPLETED
Acute Myocardial Infarction
Ludwig-Maximilians - University of Munich
2008-03 PHASE2; PHASE3
NCT01257464 TERMINATED
Cystic Fibrosis
University of British Columbia
2010-09 PHASE2
NCT00820573 COMPLETED
Diabetes
The University of Texas Health Science Center at San Antonio
2009-10 PHASE4
NCT01378117 COMPLETED
Type 2 Diabetes Mellitus; Hospitalization; Hyperglycemia
Emory University
2011-08 PHASE4
NCT01405911 COMPLETED
Glucose Intolerance
Merck Sharp & Dohme LLC
2011-08-16 PHASE2
NCT01408888 COMPLETED
Diabetes Mellitus, Type 2
Eli Lilly and Company
2011-08 PHASE1
NCT01177813 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2010-07 PHASE3
NCT01338870 COMPLETED
Diabetes Mellitus, Type 2
Pfizer
2011-06 PHASE2
NCT01137812 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2010-07 PHASE3
NCT01336738 COMPLETED
Diabetes, Type 2
Pfizer
2011-06 PHASE2
NCT01296412 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2011-03-11 PHASE3
NCT00838903 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2009-02 PHASE3
NCT01100125 COMPLETED
Diabetes
Seoul National University Bundang Hospital
2010-04 PHASE4
NCT02607410 COMPLETED
Type 2 Diabetes Mellitus
University of Sao Paulo General Hospital
2010-01 PHASE4
NCT01006018 TERMINATED
Prediabetic State
Emory University
2011-07
NCT00673894 COMPLETED
Type 2 Diabetes
Garvan Institute of Medical Research
2008-04
NCT01106690 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2010-06 PHASE3
NCT01096277 UNKNOWN
Type 2 Diabetes Mellitus
Hannover Medical School
2010-10 PHASE4
NCT01441232 COMPLETED
Type 2 Diabetes Mellitus
Lexicon Pharmaceuticals
2011-10 PHASE1
NCT01106677 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2010-05 PHASE3
NCT00998686 TERMINATED
Type 2 Diabetes Mellitus
Phenomix
2009-11 PHASE3
NCT01195090 COMPLETED
Type 2 Diabetes
Sung-Chen Liu
2009-10 PHASE4
NCT01340768 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2010-06-22 PHASE3
NCT01624116 COMPLETED
Diabetes, Type 2
Services Hospital, Lahore
2011-08
NCT01235819 COMPLETED
Type 1 Diabetes
Command Hospital, India
2010-11 PHASE4
NCT00958269 TERMINATED
Type 2 Diabetes Mellitus; Renal Impairment
Phenomix
2009-08 PHASE3
NCT00851903 COMPLETED
Diabetes Mellitus, Type 2
Sanofi
2009-06 PHASE3
NCT01081834 COMPLETED
Diabetes Mellitus, Type 2
Janssen Research & Development, LLC
2010-03 PHASE3
NCT01076075 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2010-06-03 PHASE3
NCT01092663 COMPLETED
Diabetes Mellitus, Type 2
KineMed
2010-03
NCT01112670 COMPLETED
Healthy
University of Colorado, Denver
2009-11 PHASE4
NCT01169090 COMPLETED
Type 2 Diabetes
Kowa Research Institute, Inc.
2010-07 PHASE2
NCT00751114 COMPLETED
Diabetes Mellitus, Type 2
Sanofi
2008-11 PHASE4
NCT00768651 COMPLETED
Type 1 Diabetes
University of Alberta
2008-10 PHASE2
NCT01193296 COMPLETED
Type 2 Diabetes Mellitus
Novartis
2010-06 PHASE4
NCT01093651 COMPLETED
Diabetes; Insulin Resistance
Washington University School of Medicine
2010-06 PHASE2; PHASE3
NCT01602003 COMPLETED
Type 2 Diabetes Mellitus
LG Life Sciences
2009-12 PHASE3
NCT00961363 UNKNOWN
Impaired Glucose Tolerance
National Taiwan University Hospital
2009-12 PHASE2
NCT00881530 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2009-03 PHASE2
NCT00885638 COMPLETED
Healthy; Type 2 Diabetes
Lund University
2009-08 PHASE4
NCT00939939 TERMINATED
Diabetes Mellitus Type 2
Ludwig-Maximilians - University of Munich
2010-03 PHASE4
NCT00770081 COMPLETED
Diabetes Mellitus, Type 2; Renal Insufficiency
Novartis
2008-09 PHASE3
NCT01422590 COMPLETED
Type 2 Diabetes Mellitus
Samsung Medical Center
2010-05 PHASE1
NCT00509262 COMPLETED
Diabetes Mellitus, Type 2; Renal Insufficiency, Chronic
Merck Sharp & Dohme LLC
2007-10-09 PHASE3
NCT00509236 COMPLETED
Diabetes Mellitus, Type 2; End-Stage Kidney Disease
Merck Sharp & Dohme LLC
2007-10-19 PHASE3
NCT00860288 COMPLETED
Diabetes Mellitus, Type 2
Novartis Pharmaceuticals
2009-02 PHASE2; PHASE3
NCT00984867 COMPLETED
Type 2 Diabetes
AstraZeneca
2009-10 PHASE3
NCT00976937 COMPLETED
Type 2 Diabetes Mellitus
Sanofi
2009-08 PHASE3
NCT00837759 TERMINATED
Diabetes Mellitus Type 1; Autoimmune Diabetes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2009-02 PHASE2
NCT00754988 COMPLETED
Diabetes Mellitus Type 2
Hoffmann-La Roche
2008-10 PHASE3
NCT00657280 COMPLETED
Heart Failure, Congestive
Stanford University
2008-04 EARLY_PHASE1
NCT01059825 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2010-02-24 PHASE2
NCT00466518 COMPLETED
Kidney Transplant; Type 2 Diabetes
University of Oklahoma
2007-04
NCT00730275 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2008-07-18 PHASE1
NCT00847080 COMPLETED
Reactive Hypoglycemia
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
2008-12 PHASE4
NCT00885352 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2009-04-15 PHASE3
NCT01131182 COMPLETED
Type 2 Diabetes Mellitus (T2DM)
Merck Sharp & Dohme LLC
2010-06-13 PHASE4
NCT00627744 COMPLETED
Myocardial Infarction; Unstable Angina Pectoris; Diabetes Mellitus; Impaired Glucose Tolerance
Karolinska Institutet
2008-05 PHASE4
NCT01046110 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2010-01 PHASE3
NCT00722371 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-09-05 PHASE3
NCT01034111 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2010-03-01 PHASE3
NCT00957060 COMPLETED
Diabetes Mellitus, Type 2
Sanofi
2009-07 PHASE4
NCT00616811 COMPLETED
Diabetes Mellitus, Type 2
Novartis
2008-01 PHASE3
NCT00976261 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2009-10-17 PHASE1
NCT00747383 COMPLETED
Type 2 Diabetes Mellitus
The Royal Bournemouth Hospital
2008-09
NCT00837577 COMPLETED
Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2009-02-05 PHASE3
NCT00813995 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-12-09 PHASE3
NCT01089790 TERMINATED
Diabetes Mellitus, Type 2
Forest Laboratories
2010-03 PHASE3
NCT01035879 COMPLETED
Diabetes
Gilead Sciences
2009-12 PHASE2
NCT00676338 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2008-11 PHASE3
NCT01093794 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2010-04 PHASE1
NCT00901979 COMPLETED
Type 2 Diabetes Mellitus
Novartis Pharmaceuticals
2009-04 PHASE2
NCT00732121 UNKNOWN
Type 2 Diabetes
University of Vermont
2008-08 PHASE4
NCT00699322 UNKNOWN
Type 2 Diabetes
The Catholic University of Korea
2008-06 PHASE4
NCT00969566 COMPLETED
Diabetes
Seoul National University Bundang Hospital
2009-01 PHASE4
NCT00855166 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2009-02 PHASE3
NCT00936663 TERMINATED
Type 2 Diabetes; End Stage Renal Disease
University of Nebraska
2009-07-06 PHASE4
NCT01095991 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2010-03 PHASE1
NCT00704132 COMPLETED
Type 2 Diabetes Mellitus (T2DM)
Merck Sharp & Dohme LLC
2007-02-14 PHASE1
NCT01128621 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2009-11-23 PHASE2
NCT00870194 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2009-03 PHASE4
NCT01119846 COMPLETED
Diabetes Mellitus, Type 2
GlaxoSmithKline
2009-06-05 PHASE2
NCT00686634 COMPLETED
Type 2 Diabetes Mellitus
Charles Drew University of Medicine and Science
2008-01 PHASE4
NCT01104532 COMPLETED
Healthy; Pharmacokinetics of ASP1941
Astellas Pharma Inc
2010-02 PHASE1
NCT00541450 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-01-15 PHASE3
NCT00978796 COMPLETED
Type 1 Diabetes
University of Colorado, Denver
2009-09 PHASE4
NCT00968006 COMPLETED
Type 2 Diabetes Mellitus
University of Padova
2009-10 PHASE4
NCT00545584 COMPLETED
Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2007-04-01 PHASE3
NCT00833027 COMPLETED
Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-03-01 PHASE4
NCT00532935 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-01-26 PHASE3
NCT00749190 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2008-08 PHASE2
NCT00766441 TERMINATED
Diabetes; Hypoglycemia
University of Manchester
2008-08 PHASE4
NCT00780715 COMPLETED
Diabetes Mellitus, Type 2
University of Dundee
2008-12 PHASE4
NCT00729326 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2008-08 PHASE4
NCT00701090 COMPLETED
Type 2 Diabetes Mellitus, Non Insulin Dependent; Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2008-05 PHASE3
NCT00832624 TERMINATED
Diabetes Mellitus Non-insulin-dependent
Merck Sharp & Dohme LLC
2008-11-26 PHASE4
NCT00960453 COMPLETED
Diabetes Mellitus
Seoul National University Hospital
2008-12 PHASE1
NCT00420511 COMPLETED
Type 2 Diabetes Mellitus
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
2007-01 PHASE2
NCT00789191 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2008-11 PHASE3
NCT00666848 COMPLETED
Metabolic Syndrome; Hypertension
Vanderbilt University
2008-03 PHASE4
NCT00871507 COMPLETED
Diabetes Mellitus, Type 2
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2009-04 PHASE1
NCT00425490 COMPLETED
Diabetes Mellitus Type 2
Sheba Medical Center
2007-01 PHASE3
NCT02172196 COMPLETED
Healthy
Boehringer Ingelheim
2009-05 PHASE1
NCT00888238 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2009-05-12 PHASE1
NCT00696982 UNKNOWN
Diabetes Mellitus; Arterial Stiffness
Assaf-Harofeh Medical Center
2008-06
NCT00700817 COMPLETED
Diabetes; Diabetes Mellitus, Type 2
Novo Nordisk A/S
2008-06 PHASE3
NCT00842556 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2009-03 PHASE1
NCT00783549 COMPLETED
Dyslipidaemias
GlaxoSmithKline
2008-09-04 PHASE1
NCT00666458 COMPLETED
Type 2 Diabetes
AstraZeneca
2008-04 PHASE3
NCT00511108 COMPLETED
Type 2 Diabetes Mellitus (T2DM)
Merck Sharp & Dohme LLC
2007-07-11 PHASE1
NCT00637273 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2008-01 PHASE3
NCT01028391 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2007-09-01 PHASE3
NCT00660075 COMPLETED
Diabetes Mellitus; Postprandial Lipemia
Laval University
2008-02 PHASE3
NCT00642278 COMPLETED
Diabetes Mellitus, Type II; Diabetes Mellitus, Non Insulin Dependent
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2008-04 PHASE2
NCT00631488 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2008-02 PHASE2
NCT00551590 COMPLETED
Type 2 Diabetes Mellitus
Ludwig-Maximilians - University of Munich
2007-12 PHASE1
NCT00364377 COMPLETED
Pre-diabetes
Mayo Clinic
2006-08 PHASE4
NCT00482729 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2007-06-19 PHASE3
NCT00716092 COMPLETED
Diabetes Mellitus, Type 2
Boehringer Ingelheim
2008-07 PHASE2
NCT00795275 COMPLETED
Obesity
University of Colorado, Denver
2008-01
NCT00395343 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-12-11 PHASE3
NCT00971659 COMPLETED
Type 2 Diabetes
Profil Institut für Stoffwechselforschung GmbH
2008-01 PHASE1
NCT00449930 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2007-03-01 PHASE3
NCT00832390 COMPLETED
Diabetes Mellitus
Merck Sharp & Dohme LLC
2007-02-14 PHASE4
NCT00397631 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-12-19 PHASE3
NCT00875394 COMPLETED
Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2007-02-01 PHASE3
NCT00541229 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2007-08-24 PHASE1
NCT00501657 COMPLETED
Gastroparesis; Diabetes Mellitus
Royal Adelaide Hospital
2007-07 PHASE1
NCT00484419 COMPLETED
Type 2 Diabetes; Hyperlipidemia
Daiichi Sankyo
2007-05 PHASE3
NCT00305604 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2006-03-08 PHASE3
NCT00760344 COMPLETED
Diabetes Mellitus
Takeda
2007-03 PHASE2
NCT00642798 COMPLETED
Diabetes Mellitus Non-insulin-dependent
Merck Sharp & Dohme LLC
2008-03 PHASE1
NCT00929201 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2008-01 PHASE1
NCT00372060 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-08-21 PHASE3
NCT00363844 COMPLETED
Type 2 Diabetes Mellitus
Ono Pharmaceutical Co., Ltd.
2006-08 PHASE3
NCT00363948 COMPLETED
Type 2 Diabetes Mellitus
Ono Pharmaceutical Co., Ltd.
2006-08 PHASE3
NCT00363519 COMPLETED
Type 2 Diabetes Mellitus
Ono Pharmaceutical Co., Ltd.
2006-08 PHASE3
NCT00961480 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2007-10 PHASE1
NCT00350779 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-06-12 PHASE3
NCT00477581 COMPLETED
Type 2 Diabetes Mellitus
AstraZeneca
2007-05 PHASE4
NCT00411554 COMPLETED
Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2007-01 PHASE3
NCT00337610 COMPLETED
Type 2 Diabetes Mellitus (T2DM)
Merck Sharp & Dohme LLC
2006-06 PHASE3
NCT00541775 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-06 PHASE3
NCT00289848 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2006-03 PHASE3
NCT00095056 COMPLETED
Diabetes Mellitus, Type 2; Chronic Renal Insufficiency
Merck Sharp & Dohme LLC
2004-10 PHASE3
NCT00106704 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2005-03 PHASE3
NCT00094770 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2004-09 PHASE3
NCT00127192 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2005-07 PHASE2
NCT00975052 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2006-01 PHASE1
NCT00758069 COMPLETED
Diabetes Mellitus, Non-Insulin-Dependent
Merck Sharp & Dohme LLC
2005-07-03 PHASE2
NCT00961857 COMPLETED
Type 2 Diabetes
Merck Sharp & Dohme LLC
2005-12-01 PHASE1
NCT00086502 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2004-06 PHASE3
NCT00094757 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2004-10-06 PHASE3
NCT00086515 COMPLETED
Diabetes Mellitus, Type II
Merck Sharp & Dohme LLC
2004-06-30 PHASE3
NCT00087516 COMPLETED
Diabetes Mellitus, Type 2
Merck Sharp & Dohme LLC
2004-06 PHASE3
NCT00371007 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2004-06-01 PHASE2
NCT00944450 COMPLETED
Type 2 Diabetes Mellitus
Merck Sharp & Dohme LLC
2004-08 PHASE1
NCT00482079 COMPLETED
Diabetes Mellitus, Type II
Merck Sharp & Dohme LLC
2003-05-13 PHASE2
NCT00481663 COMPLETED
Type II Diabetes Mellitus
Merck Sharp & Dohme LLC
2003-08-19 PHASE2
NCT00696826 COMPLETED
Liver Insufficiency
Merck Sharp & Dohme LLC
2004-04 PHASE1
NCT00418366 COMPLETED
Renal Insufficiency; Hemodialysis
Merck Sharp & Dohme LLC
2003-01 PHASE1
NCT01054118 COMPLETED
Diabetes Mellitus, Type 2
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
2009-12 PHASE1

(data from https://clinicaltrials.gov, updated on 2026-02-18)

Check the Sitagliptin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Sitagliptin is a highly selective oral inhibitor of dipeptidyl peptidase-4 (DPP-4) that competitively binds the active site of the enzyme to block the cleavage and degradation of endogenous incretin hormones, including glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. By sustaining active incretin concentrations, sitagliptin stimulates glucose-dependent insulin secretion from pancreatic beta cells and suppresses glucagon release, providing significant glycemic control in clinical evaluations for type 2 diabetes mellitus.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.