Selinexor (KPT-330) is a potent, selective, and orally bioavailable XPO1 inhibitor. It affects p53, PI3K/AKT, and NF-κB signaling pathways. By blocking the nuclear export of tumor suppressor proteins, it effectively inhibits cancer cell proliferation and induces apoptosis.
Selinexor (KPT-330) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Selinexor (KPT-330) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.