CAS No. 473727-83-2
Batch:
Purity:99.68
Chemical Structure
Check the
Navarixin (SCH-527123)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide | |
|---|---|---|
| CAS Number | 473727-83-2 | |
| Molecular Formula |
C21H23N3O5 |
|
| Molecular Weight (MW) | 397.42 | |
| SMILES | CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C | |
| InChIKey | RXIUEIPPLAFSDF-CYBMUJFWSA-N |
Navarixin (SCH-527123) is an orally bioavailable antagonist targeting CXCR2 and CXCR1 (IC50 36 nM). By inhibiting CXC chemokine receptor signaling, Navarixin blocks downstream intracellular calcium mobilization, myeloperoxidase release, and neutrophil chemotaxis. This CXCR1/CXCR2 blockade effectively suppresses neutrophil recruitment and mitigates chemokine-driven inflammatory responses in preclinical cell and tissue models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
79 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 79 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Navarixin (SCH-527123) Clinical Trials
- Navarixin (SCH-527123) Solubility in DMSO
- Navarixin (SCH-527123) Stock Solution
- Navarixin (SCH-527123) Storage
- Navarixin (SCH-527123) Stability
- Navarixin (SCH-527123) Molecular Weight
- Navarixin (SCH-527123) SMILES
- Navarixin (SCH-527123) Chemical Structure (2D and 3D)
- Navarixin (SCH-527123) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.