CAS No. 1523406-39-4
Batch:
Purity:99.79
Chemical Structure
Check the
SAR405
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (8S)-9-[(5-chloro-3-pyridinyl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one | |
|---|---|---|
| CAS Number | 1523406-39-4 | |
| Molecular Formula |
C19H21ClF3N5O2 |
|
| Molecular Weight (MW) | 443.85 | |
| SMILES | CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F | |
| InChIKey | SPDQRCUBFSRAFI-DOMZBBRYSA-N |
Biological Activity
SAR405 is a highly selective low-molecular-mass kinase inhibitor of PIK3C3/Vps34 (Kd 1.5 nM) that demonstrates no significant activity against class I and class II PI3Ks or mTOR up to. By targeting Vps34 within the autophagy machinery, SAR405 prevents autophagosome formation and inhibits vesicle trafficking. Consequently, SAR405 synergizes with mTOR inhibitors to impair tumor cell proliferation. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
| DMSO |
88 mg/mL
(198.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 29 mg/mL |
| Water | Insoluble |
| DMSO |
89 mg/mL
(200.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 89 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- SAR405 Mechanism of Action: VPS34 Inhibition in Tumor Cell Research
- SAR405 Working Concentration | Cell Culture | Treatment
- SAR405 Solubility in DMSO
- SAR405 Stock Solution
- SAR405 Storage
- SAR405 Stability
- SAR405 Combination Database
- SAR405 Molecular Weight
- SAR405 SMILES
- SAR405 Chemical Structure (2D and 3D)
- SAR405 IC50 for Cell-based and Cell-free Assays
- SAR405 Sigma (AMBH303C4EB3)? Try a better option.
- SAR405 APExBIO (A8883)? Try a better option.
- SAR405 MedChemExpress (HY-12481)? Try a better option.
- SAR405 Cayman (16979)? Try a better option.
- SAR405 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.