Ruxolitinib (INCB18424): Selectivity & Specificity
Ruxolitinib (INCB18424) is a potent inhibitor of JAK (0.40 nM), JAK2 (2.8 nM), JAK1 (3.3 nM), pSTAT3 (5.73 nM), TYK2 (19 nM), JAK3 (428 nM), STAT signaling (< 100 nM), ACVR1 (6100 nM), STAT1, STAT3, STAT4, STAT5, IL6, TNF, IFNG, PAD4, ACE2, ERK1, ERK2, NRAS, KRAS, PTPN11, CALR, MPL, SH2B3, IL2, IL4, IL7, IL15, IL21. Ruxolitinib (INCB18424) exhibits the greatest inhibitory potency toward JAK (IC50 = 0.40 nM).