SMILES:
C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Chemical Structure
Check the
Ruxolitinib (INCB18424)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile | |
|---|---|---|
| CAS Number | 941678-49-5 | |
| Molecular Formula |
C17H18N6 |
|
| Molecular Weight (MW) | 306.37 | |
| SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 | |
| InChIKey | HFNKQEVNSGCOJV-OAHLLOKOSA-N |
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
300 mg/mL
(979.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
| DMSO |
300 mg/mL
(979.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
| DMSO |
61 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 30 mg/mL |
| Water | Insoluble |
| DMSO |
61 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
| DMSO |
61 mg/mL
(199.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
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- Ruxolitinib (INCB18424) Working Concentration | Cell Culture | Treatment
- Ruxolitinib (INCB18424) Solubility in DMSO
- Ruxolitinib (INCB18424) Storage
- Ruxolitinib (INCB18424) Stability
- Ruxolitinib (INCB18424) Combination Database
- Ruxolitinib (INCB18424) Molecular Weight
- Ruxolitinib (INCB18424) CAS Number
- Ruxolitinib (INCB18424) Chemical Structure (2D and 3D)
- Ruxolitinib (INCB18424) IC50 for Cell-based and Cell-free Assays
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- Ruxolitinib (INCB18424) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.