Cell-free Assays (IC50/Ki) for Ruxolitinib (INCB18424)

Key TargetIC50 (Cell-free)DescriptionReference
JAK1 kinase 3.3 nM Derived from Table 1, specific assay method not detailed in this text. Download PDF
JAK2 kinase 2.8 nM Derived from Table 1, specific assay method not detailed in this text. Download PDF
JAK3 kinase 428 nM Derived from Table 1, specific assay method not detailed in this text. Download PDF
TYK2 kinase 19 nM Derived from Table 1, specific assay method not detailed in this text. Download PDF
JAK2 enzyme 23.66 ±1.76 nM ADP-Glo™ kinase assay ([Vendor] Corporation), luminescence measurement. PMC12395164

Cell-based Assay (IC50) for Ruxolitinib (INCB18424)

Cell TypeIC50 (Cell-based)DescriptionReference
MDAH 24188 nM cell proliferation assays PMC12254336
OVSAHO 19771 nM cell proliferation assays PMC12254336
SKOV3 39073 nM cell proliferation assays PMC12254336
JHOC5 21287 nM cell proliferation assays PMC12254336
PEO1 20406 nM cell proliferation assays PMC12254336
Check the Ruxolitinib (INCB18424) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

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