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Romidepsin (FK228) SDS | MSDS
1.PRODUCT AND COMPANY IDENTIFICATION
Product identifier
- Product Name: Romidepsin (FK228)
- Catalog Number: S3020
- CAS Number: 128517-07-7
- IUPAC Name: Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company : Selleck Chemicals
- TollFree : +1 877 796-6397
- Tel : +1 832 582-8158
- Fax : +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2. HAZARDS IDENTIFICATION
GHS classification in accordance with the OSHA Hazard Communication Standard (29 CFR 1910.1200): Not a hazardous substance or mixture.
Other hazards: None known.
GHS label elements: Not a hazardous substance or mixture.
3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance / Mixture: Substance
Components: No hazardous ingredients.
4. FIRST AID MEASURES
If inhaled: After inhalation: fresh air.
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/shower.
In case of eye contact: After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed: After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.
Most important symptoms and effects, both acute and delayed: The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11.
Protection of first-aiders: For personal protection see section 8.
Notes to physician: N/A.
5. FIREFIGHTING MEASURES
Unsuitable extinguishing media: For this substance/mixture no limitations of extinguishing agents are given.
Hazardous combustion products: Carbon oxides, Nitrogen oxides (NOx), Sulphur oxides.
Specific extinguishing methods: N/A.
Further information: Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters: In the event of fire, wear self-contained breathing apparatus.
6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures:
Advice for non-emergency personnel: Avoid inhalation of powder. Evacuate the danger area, observe emergency procedures, consult an expert.
Advice for emergency responders: For personal protection see section 8.
Environmental precautions: Do not let product enter drains.
Methods and materials for containment and cleaning up: Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of powder.
7. HANDLING AND STORAGE
Precautions for safe handling: For precautions see section 2.2.
Further information on storage conditions: Tightly closed. Dry.
Storage class: 11, Combustible Solids.
Recommended storage temperature: -4 °F / -20 °C.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Ingredients with workplace control parameters: Contains no substances with occupational exposure limit values.
Engineering measures: N/A.
Personal protective equipment:
- Respiratory protection: Required when powder is generated. Recommended Filter type: Filter type P1. Maintenance, cleaning, and testing must be carried out according to producer instructions and properly documented.
- Hand protection: Handle with impervious gloves. Nitrile rubber gloves are recommended (0.11 mm thickness, 480 min breakthrough time).
- Eye protection: Use safety glasses tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).
- Hygiene measures: Change contaminated clothing. Wash hands after working with substance.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: powder
Color: N/A
Odor: N/A
Odor Threshold: N/A
pH: N/A
Melting point: N/A
Boiling point/boiling range: N/A
Flash point: N/A
Evaporation rate: N/A
Flammability (solid, gas): N/A
Flammability (liquids): N/A
Burning rate: N/A
Upper explosion limit / Upper flammability limit: N/A
Lower explosion limit / Lower flammability limit: N/A
Vapor pressure: N/A
Relative vapour density: N/A
Relative density: N/A
Density: N/A
Water solubility: N/A
Partition coefficient: n-octanol/water: N/A
Autoignition temperature: N/A
Decomposition temperature: N/A
Viscosity, dynamic: N/A
Viscosity, kinematic: N/A
Flow time: N/A
Explosive properties: N/A
Oxidizing properties: N/A
Molecular weight: 540.70 g/mol
Particle size: N/A
10. STABILITY AND REACTIVITY
Reactivity: N/A.
Chemical stability: The product is chemically stable under standard ambient conditions (room temperature).
Possibility of hazardous reactions: N/A.
Conditions to avoid: No information available.
Incompatible materials: Strong oxidizing agents.
Hazardous decomposition products: In the event of fire: see section 5.
11. TOXICOLOGICAL INFORMATION
Acute toxicity:
- Oral: N/A
- Inhalation: N/A
- Dermal: N/A
- LD50 Intraperitoneal - 6.4 mg/kg
- LD50 Intravenous - 10 mg/kg
Skin corrosion/irritation: N/A.
Serious eye damage/eye irritation: N/A.
Respiratory or skin sensitization: N/A.
Germ cell mutagenicity: N/A.
Carcinogenicity:
- IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
- ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
- NTP: No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
- OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA's list of regulated carcinogens.
Reproductive toxicity: N/A.
Specific target organ toxicity - single exposure: N/A.
Specific target organ toxicity - repeated exposure: N/A.
Aspiration hazard: N/A.
Additional Information: RTECS: YV9399000. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12. ECOLOGICAL INFORMATION
No specific data provided for this section.
13. DISPOSAL CONSIDERATIONS
Waste from residues: Waste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.
14. TRANSPORT INFORMATION
IATA-DGR: Not regulated as a dangerous good.
IMDG-Code: Not regulated as a dangerous good.
Transport in bulk according to IMO instruments: Not applicable for product as supplied.
49 CFR Road: Not regulated as a dangerous good.
Poison Inhalation Hazard: No.
Special precautions for user: Not classified as dangerous in the meaning of transport regulations.
15. REGULATORY INFORMATION
CERCLA Reportable Quantity
This material does not contain any components with a CERCLA RQ.
SARA 304 Extremely Hazardous Substances Reportable Quantity
This material does not contain any components with a section 304 EHS RQ.
SARA 302 Extremely Hazardous Substances Threshold Planning Quantity
Components CAS-No. Component TPQ (lbs)
SARA 311/312 : No SARA Hazards
Hazards
SARA 313 : This material does not contain any chemical
components with known CAS numbers that exceed the
threshold (De Minimis) reporting levels established by
SARA Title III, Section 313.
US State Regulations
Massachusetts Right To Know
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 128517-07-7
New Jersey Right To Know
Cyclo[(2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl], cyclic (3→5)-disulfide 128517-07-7
California Prop. 65
This product does not contain any chemicals known to State of California to cause cancer,
birth defects, or any other reproductive harm.
The components of this product are reported in the following inventories:
TSCA : Product contains substance(s) not listed on TSCA
inventory.
TSCA list
No substances are subject to a Significant New Use Rule.
No substances are subject to TSCA 12(b) export notification requirements.
16. OTHER INFORMATION
Revision Date: 2026/07/24
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.